From transformation to chronification of migraine: pathophysiological and clinical aspects

Torres-Ferrús, M. (M.); Ursitti, F. (F.); Alpuente, A. (A.); Brunello, F. (F.); Chiappino, D. (D.); Vries, T. (T.) de; Di-Marco, S. (S.); Ferlisi, S. (S.); Guerritore, L. (L.); González-García, N. (N.); González-Martínez, A. (Álvaro); Khutorov, D. (D.); Kritsilis, M. (M.); Kyrou, A. (A.); Makeeva, T. (T.); Mínguez-Olaondo, A. (Ane); Pilati, L. (L.); Serrien, A. (A.); Tsurkalenko, O. (O.); Van-den-Abbeele, D. (D.); Hoogstraten, W.S. (W. S.); Lampl, C. (Christian)

Keywords:

Chronic migraine
Transformation
Pathophysiology
Risk factors
Genetics
Biomarker
Neurophysiology
Neuroimaging,
Animal models

Issue Date:

2020

Publisher:

MDPI AG

ISSN:

1129-2369

Note:

This article is licensed under a Creative Commons Attribution 4.0 International License

Citation:

Torres-Ferrús, M. (M.); Ursitti, F. (F.); Alpuente, A. (A.); et al. "From transformation to chronification of migraine: pathophysiological and clinical aspects". Journal of headache pain. 21 (42), 2020,

Abstract

Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from different perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiological, genetic, molecular, structural, functional, physiological and preclinical evidence available.

URI:

https://hdl.handle.net/10171/66616

DOI:

10.1186/s10194-020-01111-8

Appears in Collections:

DA - CUN - Neurología - Artículos de revista

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