Full metadata record
DC Field | Value | Language |
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dc.creator | Li, W. (Weihua) | - |
dc.creator | Lao-Kaim, N.P. (Nick P.) | - |
dc.creator | Roussakis, A.A. (Andreas-Antonios) | - |
dc.creator | Martín-Bastida, A. (Antonio) | - |
dc.creator | Valle-Guzman, N. (Natalie) | - |
dc.creator | Paul, G. (Gesine) | - |
dc.creator | Soreq, E. (Eyal) | - |
dc.creator | Daws, R.E. (Richard E.) | - |
dc.creator | Foltynie, T. (Thomas) | - |
dc.creator | Barker, R.A. (Roger A.) | - |
dc.creator | Hampshire, A. (Adam) | - |
dc.creator | Piccini, P. (Paola) | - |
dc.date.accessioned | 2023-06-29T11:17:26Z | - |
dc.date.available | 2023-06-29T11:17:26Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Li, W. (Weihua); Lao-Kaim, N.P. (Nick P.); Roussakis, A.A. (Andreas-Antonios); et al. "Longitudinal functional connectivity changes related to dopaminergic decline in Parkinson’s disease". NeuroImage: Clinical. 28, 2020, 102409 | es |
dc.identifier.issn | 2213-1582 | - |
dc.identifier.uri | https://hdl.handle.net/10171/66719 | - |
dc.description.abstract | Background: Resting-state functional magnetic resonance imaging (fMRI) studies have demonstrated that basal ganglia functional connectivity is altered in Parkinson’s disease (PD) as compared to healthy controls. However, such functional connectivity alterations have not been related to the dopaminergic deficits that occurs in PD over time. Objectives: To examine whether functional connectivity impairments are correlated with dopaminergic deficits across basal ganglia subdivisions in patients with PD both cross-sectionally and longitudinally. Methods: We assessed resting-state functional connectivity of basal ganglia subdivisions and dopamine transporter density using 11C-PE2I PET in thirty-four PD patients at baseline. Of these, twenty PD patients were rescanned after 19.9 ± 3.8 months. A seed-based approach was used to analyze resting-state fMRI data. 11CPE2I binding potential (BPND) was calculated for each participant. PD patients were assessed for disease severity. Results: At baseline, PD patients with greater dopaminergic deficits, as measured with 11C-PE2I PET, showed larger decreases in posterior putamen functional connectivity with the midbrain and pallidum. Reduced functional connectivity of the posterior putamen with the thalamus, midbrain, supplementary motor area and sensorimotor cortex over time were significantly associated with changes in DAT density over the same period. Furthermore, increased motor disability was associated with lower intraregional functional connectivity of the posterior putamen. Conclusions: Our findings suggest that basal ganglia functional connectivity is related to integrity of dopaminergic system in patients with PD. Application of resting-state fMRI in a large cohort and longitudinal scanning may be a powerful tool for assessing underlying PD pathology and its progression. | es_ES |
dc.description.sponsorship | The TransEuro study received funding from an FP7 EU Consortium. The Medical Research Council (MRC) co-funded the PET scans along with the FP7 EU Consortium. An NIHR award of Biomedical Research Centre to the University of Cambridge/ Addenbrooke’s Hospital and Imperial College London supported part of this study. Travel of Lund patients with staff has been funded by local grants in addition to TransEuro (Swedish Parkinson Academy, Regional Academic Learning Grants, and Multipark). | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Parkinson’s disease | es_ES |
dc.subject | Resting-state functional magnetic resonance imaging | es_ES |
dc.subject | Functional connectivity | es_ES |
dc.subject | 11C-PE2I | es_ES |
dc.subject | Dopamine transporter | es_ES |
dc.title | Longitudinal functional connectivity changes related to dopaminergic decline in Parkinson’s disease | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | es_ES |
dc.identifier.doi | 10.1016/j.nicl.2020.102409 | - |
dadun.citation.publicationName | NeuroImage: Clinical | es_ES |
dadun.citation.startingPage | 102409 | es_ES |
dadun.citation.volume | 28 | es_ES |
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