Seroprevalence and socioeconomic impact of the first SARS-CoV-2 infection wave in a small town in Navarre, Spain

Ribes, M. (Marta); Montaña-López, J. (Julia); Vidal, M. (Marta); Aguilar, R. (Ruth); Nicolas, P. (Patricia); Alfonso, U. (Uxue); Rodrigo, N. (Natalia); Carolis, C. (Carlo); Dobaño, C. (Carlota); Moncunill, G. (Gemma); Chaccour, C.J. (Carlos J.)

Keywords:

Antibody
SARS-CoV-2
COVID-19
socioeconomic impact

Issue Date:

2023

Publisher Version:

https://pubmed.ncbi.nlm.nih.gov/36890175/

ISSN:

2045-2322

Note:

Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Citation:

Ribes, M.; Montañà, J.; Vidal, M.; et al. "Seroprevalence and socioeconomic impact of the first SARS-CoV-2 infection wave in a small town in Navarre, Spain". Scientific reports. 13 (1), 2023, 3862

Abstract

The characterization of the antibody response to SARS-CoV-2 and its determinants are key for the understanding of COVID-19. The identification of vulnerable populations to the infection and to its socioeconomic impact is indispensable for inclusive policies. We conducted an age-stratified cross-sectional community-based seroprevalence survey between June 12th and 19th 2020-during the easing of lockdown-in Cizur, Spain. We quantified IgG, IgM and IgA levels against SARS-CoV-2 spike and its receptor-binding domain in a sample of 728 randomly selected, voluntarily registered inhabitants. We estimated a 7.9% seroprevalence in the general population, with the lowest seroprevalence among children under ten (n = 3/142, 2.1%) and the highest among adolescents (11-20 years old, n = 18/159, 11.3%). We found a heterogeneous immune-response profile across participants regarding isotype/antigen-specific seropositivity, although levels generally correlated. Those with technical education level were the most financially affected. Fifty-five percent had visited a supermarket and 43% a sanitary centre since mid-February 2020. When comparing by gender, men had left the household more frequently. In conclusion, few days after strict lockdown, the burden of SARS-CoV-2 infection was the lowest in children under 10. The findings also suggest that a wider isotype-antigen panel confers higher sensitivity. Finally, the economic impact biases should be considered when designing public health measures.

URI:

https://hdl.handle.net/10171/67306

DOI:

10.1038/s41598-023-30542-x

Appears in Collections:

DA - CUN - Medicina interna - Artículos de revista

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