Biomarkers of delirium risk in older adults: a systematic review and meta-analysis

Lozano-Vicario, L. (Lucía); García-Hermoso, A. (Antonio); Cedeño-Veloz, B.A. (Bernardo Abel); Fernandez-Irigoyen, J. (Joaquín); Santamaria, E. (Enrique); Romero-Ortuno, R. (Román); Zambom-Ferraresi, F. (Fabricio); Sáez-de-Asteasu, M.L. (Mikel L.); Muñoz-Vázquez, Á.J. (Ángel Javier); Izquierdo, M. (Mikel); Martínez-Velilla, N. (Nicolás)

Keywords:

Área de Medicina Clínica y Epidemiología
Delirium
Older people
Neuroinflammation
Biomarkers
Cognitive impairment
Cognitive impairment

Issue Date:

2023

Publisher Version:

https://pubmed.ncbi.nlm.nih.gov/37251808/

ISSN:

1663-4365

Note:

This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Citation:

Lozano-Vicario, L.; García-Hermoso, A.; Cedeno-Veloz, B. A.; et al. "Biomarkers of delirium risk in older adults: a systematic review and meta-analysis". Frontiers in aging neuroscience. 15, 2023, 1174644

Abstract

Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-alpha] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF-alpha, and IL-6 were the most consistent biomarkers of delirium in older patients.

URI:

https://hdl.handle.net/10171/67319

DOI:

10.3389/fnagi.2023.1174644

Appears in Collections:

DA - CUN - Cirugía ortopédica y traumatología - Artículos de revista

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