Full metadata record
DC Field | Value | Language |
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dc.creator | Aramendía-Vidaurreta, V. (Verónica) | - |
dc.creator | Solis-Barquero, S.M. (Sergio M.) | - |
dc.creator | Ezponda, A. (Ana) | - |
dc.creator | Vidorreta, M. (Marta) | - |
dc.creator | Echeverría-Chasco, R. (Rebeca) | - |
dc.creator | Pascual, M. (Marina) | - |
dc.creator | Bastarrika, G. (Gorka) | - |
dc.creator | Fernández-Seara, M.A. (María A.) | - |
dc.date.accessioned | 2024-01-11T12:00:21Z | - |
dc.date.available | 2024-01-11T12:00:21Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Aramendía-Vidaurreta, V. (Verónica); Solis-Barquero, S.M. (Sergio M.); Ezponda, A. (Ana); et al. "Assessment of splenic switch-off with arterial spin labeling in adenosine perfusion cardiac MRI". Journal of Magnetic Resonance Imaging. 58 (1), 2022, 147 - 156 | es |
dc.identifier.issn | 1522-2586 | - |
dc.identifier.uri | https://hdl.handle.net/10171/68285 | - |
dc.description.abstract | Background: In patients with suspected coronary artery disease (CAD), myocardial perfusion is assessed under rest and pharmacological stress to identify ischemia. Splenic switch-off, defined as the stress to rest splenic perfusion attenuation in response to adenosine, has been proposed as an indicator of stress adequacy. Its occurrence has been previously assessed in first-pass perfusion images, but the use of noncontrast techniques would be highly beneficial. Purpose: To explore the ability of pseudo-continuous arterial spin labeling (PCASL) to identify splenic switch-off in patients with suspected CAD. Study type: Prospective. Population: Five healthy volunteers (age 24.8 ± 3.8 years) and 32 patients (age 66.4 ± 8.2 years) with suspected CAD. Field strength/sequence: A 1.5-T/PCASL (spin-echo) and first-pass imaging (gradient-echo). Assessment: In healthy subjects, multi-delay PCASL data (500-2000 msec) were acquired to quantify splenic blood flow (SBF) and determine the adequate postlabeling delay (PLD) for single-delay acquisitions (PLD > arterial transit time). In patients, single-delay PCASL (1200 msec) and first-pass perfusion images were acquired under rest and adenosine conditions. PCASL data were used to compute SBF maps and SBF stress-to-rest ratios. Three observers classified patients into "switch-off" and "failed switch-off" groups by visually comparing rest-stress perfusion data acquired with PCASL and first-pass, independently. First-pass categories were used as reference to evaluate the accuracy of quantitative classification. Statistical tests: Wilcoxon signed-rank, Pearson correlation, kappa, percentage agreement, Generalized Linear Mixed Model, Mann-Whitney, Pearson Chi-squared, receiver operating characteristic, area-under-the-curve (AUC) and confusion matrix. Significance: P value < 0.05. Results: A total of 27 patients (84.4%) experienced splenic switch-off according to first-pass categories. Comparison of PCASL-derived SBF maps during stress and rest allowed assessment of splenic switch-off, reflected in a reduction of SBF values during stress. SBF stress-to-rest ratios showed a 97% accuracy (sensitivity = 80%, specificity = 100%, AUC = 85.2%). Data conclusion: This study could demonstrate the feasibility of PCASL to identify splenic switch-off during adenosine perfusion MRI, both by qualitative and quantitative assessments. Evidence level: 2 TECHNICAL EFFICACY: 2. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Adenosine | es_ES |
dc.subject | Arterial spin labeling | es_ES |
dc.subject | Splenic switch-off | es_ES |
dc.subject | Stress cardiac MRI | es_ES |
dc.title | Assessment of splenic switch-off with arterial spin labeling in adenosine perfusion cardiac MRI | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This is an open access article under the terms of theCreative Commons Attribution-NonCommercial-NoDerivsLicense | es_ES |
dc.identifier.doi | 10.1002/jmri.28460 | - |
dadun.citation.endingPage | 156 | es_ES |
dadun.citation.number | 1 | es_ES |
dadun.citation.publicationName | Journal of Magnetic Resonance Imaging | es_ES |
dadun.citation.startingPage | 147 | es_ES |
dadun.citation.volume | 58 | es_ES |
dc.identifier.pmid | 36218288 | - |
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