Full metadata record
DC Field | Value | Language |
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dc.creator | Sanchez-Carpintero, R. (Rocío) | - |
dc.creator | Urrestarazu, E. (Elena) | - |
dc.creator | Cieza, S. (Sofía) | - |
dc.creator | Alegre-Esteban, M. (Manuel) | - |
dc.creator | Artieda, J. (Julio) | - |
dc.creator | Crespo-Eguilaz, N. (Nerea) | - |
dc.creator | Valencia, M. (Miguel) | - |
dc.date.accessioned | 2024-01-30T08:47:43Z | - |
dc.date.available | 2024-01-30T08:47:43Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Sanchez-Carpintero R, Urrestarazu E, Cieza S, Alegre M, Artieda J, Crespo-Eguilaz N, Valencia M. Abnormal brain gamma oscillations in response to auditory stimulation in Dravet syndrome. Eur J Paediatr Neurol. 2020 Jan;24:134-141 | es_ES |
dc.identifier.issn | 1532-2130 | - |
dc.identifier.uri | https://hdl.handle.net/10171/68632 | - |
dc.description.abstract | Objective: To evaluate the capability of children with Dravet syndrome to generate brain γ-oscillatory activity in response to auditory steady-state stimulation. Methods: Fifty-one subjects were included: 13 with Dravet syndrome with SCN1A gene alterations, 26 with non-Dravet epilepsies and 12 healthy controls. Responses to auditory steady-state stimulation elicited with a chirp-modulated tone between 1 and 120 Hz were collected in subjects and compared across groups. Results: Subjects with Dravet syndrome showed weak or no responses in the 1-120 Hz frequency range. Healthy controls showed oscillatory responses following the frequency of the modulation that were maximal in the low (30-70 Hz) and high (80-120) γ-ranges both, in the power and inter-trial coherence estimates. Non-Dravet epileptic children showed differences in the auditory responses when compared with the healthy controls but were able to generate oscillatory evoked activities following the frequency-varying stimulation. Conclusions: The ability to generate brain γ-oscillatory activity of children with Dravet in response to a chirp-modulated auditory stimulus is highly impaired, is not due to epilepsy and is consistent with the Nav1.1 channel dysfunction affecting interneuron activity seen in Dravet mouse models. Significance: The reported deficits in the brain oscillatory activity evoked by chirp modulated tones in children with Dravet is compatible with Dravet syndrome disease mechanisms and constitutes a potential biomarker for future disease-modifying interventions. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | es_ES |
dc.subject | Auditory evoked potentials | es_ES |
dc.subject | Dravet syndrome | es_ES |
dc.subject | Epileptic encephalopathy | es_ES |
dc.subject | Inhibitory interneurons | es_ES |
dc.subject | Oscillatory gamma activity | es_ES |
dc.title | Abnormal brain gamma oscillations in response to auditory stimulation in Dravet syndrome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1016/j.ejpn.2019.12.004 | - |
dc.identifier.pmid | 31879226 | - |
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