Capecitabine and temozolomide in grade 1/2 neuroendocrine tumors: a Spanish multicenter experience

Crespo, G. (Guillermo); Jiménez-Fonseca, P. (Paula); Custodio, A. (Ana); López, C. (Carlos); Carmona-Bayonas, A. (Alberto); Alonso, V. (Vicente); Navarro, M. (Miguel); Aller, J. (Javier); Sevilla, I. (Isabel); Grande, E. (Enrique); Gajate, P. (Pablo); Alonso-Gordoa, T. (Teresa); Matos, I. (Ignacio); Capdevila, J. (Jaume); Nieto, B. (Beatriz); Barriuso, J. (J.)

Keywords:

Capecitabine
Carcinoids
Neuroendocrine tumors
Pancreatic neuroendocrine tumors
Retrospective study
Temozolomide

Issue Date:

2016

ISSN:

1479-6694

Citation:

Crespo G, Jiménez-Fonseca P, Custodio A, López C, Carmona-Bayonas A, Alonso V, Navarro M, Aller J, Sevilla I, Grande E, Gajate P, Alonso-Gordoa T, Matos I, Capdevila J, Nieto B, Barriuso J. Capecitabine and temozolomide in grade 1/2 neuroendocrine tumors: a Spanish multicenter experience. Future Oncol. 2017 Mar;13(7):615-624. doi: 10.2217/fon-2016-0434. Epub 2016 Nov 2. PMID: 27802780.

Abstract

Background & methods: Capecitabine and temozolomide chemotherapy was used in 65 patients with grade 1/2 neuroendocrine tumors (NETs). 46 patients (70.8%) had pancreatic NETs (pNETs). Results: Response rate was 47.7%, with two complete responses (3.1%), 29 partial responses (44.6%) and 27 patients (41.5%) achieved stable disease. Median progression-free survival was 16.1 months (95% CI: 10.7-21.6) and overall survival was 38.3 months (95% CI: 24.6-51.9). Differences in progression-free survival and overall survival between pNETs and non-pNETs were not found. Nine (13.8%) patients experienced grade 3/4 toxicities, mainly thrombocytopenia (10.8%) and neutropenia (7.7%). Conclusion: This is the largest reported series of NETs treated with capecitabine and temozolomide in daily practice and shows that this combination is a promising treatment option for both grade 1/2 pNETs and non-pNETs.

URI:

https://hdl.handle.net/10171/68934

DOI:

10.2217/fon-2016-0434

Appears in Collections:

DA - CUN - Oncología médica - Artículos de revista

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