Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Gallego-Martínez, A. (Alejandro) | - |
dc.creator | Ruz-Caracuel, I. (Ignacio) | - |
dc.creator | Ramón-Patino, J. L. (Jorge L.) | - |
dc.creator | López-Janeiro, Á. (Álvaro) | - |
dc.creator | Yébenes, L. (Laura) | - |
dc.creator | Berjón, A. (Alberto) | - |
dc.creator | Hernández-Campos, A. (Alicia) | - |
dc.creator | Heredia-Soto, V. (Victoria) | - |
dc.creator | Mendiola, M. (Marta) | - |
dc.creator | Redondo, A. (Andrés) | - |
dc.creator | Peláez-García, A. (Alberto) | - |
dc.creator | Hardisson, D. (David) | - |
dc.date.accessioned | 2024-02-09T15:23:03Z | - |
dc.date.available | 2024-02-09T15:23:03Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Gallego-Martínez, A. (Alejandro); Ruz-Caracuel, I. (Ignacio); Ramón-Patino, J. L. (Jorge L.); et al. "Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma". Cancers. 11 (12), 2019, 1 - 12 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10171/69015 | - |
dc.description.abstract | Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive patterns as a prognostic factor of relapse in low-grade, early-stage EEC. Two-hundred and fifty-eight cases were selected according to the following inclusion criteria: (i) endometrioid endometrial carcinomas, (ii) grade 1 or 2 with (iii) FIGO stage I or II, and (iv) clinical follow-up. Slides were reviewed to annotate the myoinvasive pattern present in each case (infiltrative glands, microcystic, elongated and fragmented –MELF-, broad front, adenomyosis-like and adenoma malignum). Microsatellite instability was studied by immunoexpression of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6). There were 29 recurrences (11.2%) among the 258 cases analysed. A predominant broad front myoinvasive pattern was significantly associated with tumour relapse (p = 0.003). The presence of a pattern of infiltrative glands (p = 0.001) and microsatellite instability (p = 0.004) were associated with lower disease-free survival, without having an impact on overall survival. Our observations suggest the potential value of the pattern of myoinvasion as a prognostic factor in low-grade, early-stage endometrioid endometrial carcinoma. | es_ES |
dc.description.sponsorship | e Instituto de Salud Carlos III (ISCIII) (PI17/01723). | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Endometrial carcinoma | es_ES |
dc.subject | Myoinvasive pattern; | es_ES |
dc.subject | Prognosis | es_ES |
dc.subject | Microsatellite instabilit | es_ES |
dc.subject | Mismatch repair protein | es_ES |
dc.subject | Early stage | es_ES |
dc.title | Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/11/12/1845 | es_ES |
dc.editorial.note | © 2019 by the authors | es_ES |
dadun.citation.endingPage | 12 | es_ES |
dadun.citation.number | 12 | es_ES |
dadun.citation.publicationName | Cancers | es_ES |
dadun.citation.startingPage | 1 | es_ES |
dadun.citation.volume | 11 | es_ES |
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