Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Horejs, C.M. (Christine-Maria) | - |
dc.creator | St-Pierre, J.P. (Jean-Philippe) | - |
dc.creator | Ojala, J.R.M. (Juha R. M.) | - |
dc.creator | Steele, J.A.M. (Joseph A.M.) | - |
dc.creator | Barros-da-Silva, P. (Patricia) | - |
dc.creator | Rynne-Vidal, A. (Angela) | - |
dc.creator | Maynard, S.A. (Stephanie A.) | - |
dc.creator | Hansel, C.S. (Catherine S.) | - |
dc.creator | Rodríguez-Fernández, C. (Clara) | - |
dc.creator | Mazo, M. (Manuel) | - |
dc.creator | You, A.Y.F. (Amanda Y.F.) | - |
dc.creator | Wang, A.J. (Alex J.) | - |
dc.creator | Erlach, V.T. (Von Thomas) | - |
dc.creator | Tryggvason, K. (Karl) | - |
dc.creator | López-Cabrera, M. (Manuel) | - |
dc.creator | Stevens, M.M. (Molly M.) | - |
dc.date.accessioned | 2024-02-10T07:19:43Z | - |
dc.date.available | 2024-02-10T07:19:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Horejs, C.M. (Christine-Maria); St-Pierre, J.P. (Jean-Philippe); Ojala, J.R.M. (Juha R. M.); et al. "Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information". Nature Communications. 8 (15509), 2017, | es |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://hdl.handle.net/10171/69034 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin b1-chain to modulate the expression of MMP2 in this context. We demonstrate that interfacing of the b1-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor b1 and rescues tissue integrity ex vivo and in vivo in a mouse model of peritoneal fibrosis. Importantly, our data demonstrate that the membrane inhibits MMP2 expression. Changes in the expression of epithelial-to-mesenchymal transition (EMT)-related molecules further point towards a contribution of the modulation of EMT. Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations of current therapeutic approaches by enabling a localized and specific method to counteract MMP2 release applicable to a broad range of therapeutic targets. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Research | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.title | Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | CC BY | es_ES |
dc.identifier.doi | 10.1038/ncomms15509 | - |
dadun.citation.number | 15509 | es_ES |
dadun.citation.publicationName | Nature Communications | es_ES |
dadun.citation.volume | 8 | es_ES |
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