(Institución)/></a>
				</td>
				<td class= (Institución)
   (Nuevo usuario)
Ayuda  | Contacto  |  Castellano English  
 

Dadun > Depósito Académico > Facultad de Ciencias > Departamento de Genética > DA - Ciencias - Genética - Artículos de revista >

A new potential oncogenic mutation in the FERM domain of JAK2 in BCR-ABL1 negative and V617F negative chronic myeloproliferative neoplasms (CMPNs) revealed by a comprehensive screening of 17 tyrosine kinase coding genes
Autor(es) : Aranaz, P. (Paula)
Ormazábal, C. (Cristina)
Hurtado, C. (Cristina)
Erquiaga, I. (Ignacio)
Calasanz-Abinzano, M.J. (Maria Jose)
García-Delgado, M. (Marina)
Novo, F.J. (Francisco Javier)
Vizmanos, J.L. (José Luis)
Fecha incorporación: 1-may-2010
Editorial : Elsevier Inc.
Versión del editor: http://bit.ly/LeQkre
ISSN: 0165-4608
Cita: Paula Aranaz, Cristina Ormazábal, Hurtado C, Erquiaga I, Calasanz MJ, Marina García-Delgado, et al. Original article: A new potential oncogenic mutation in the FERM domain of JAK2 in BCR/ABL1-negative and V617F-negative chronic myeloproliferative neoplasms revealed by a comprehensive screening of 17 tyrosine kinase coding genes. Cancer Genet Cytogenet. 2010;199:1-8.
Resumen
BCR/ABL1-negative chronic myeloproliferative neoplasms (CMPNs) are a heterogeneous group of clonal hematological malignancies. Over recent years, some genetic events in tyrosine kinase (TK) genes have been described as causal events of these diseases. To identify new genetic aberrations underlying these diseases, we used denaturing high performance liquid chromatography and fluorescence in situ hybridization (FISH) to analyze 17 genes from two receptor-TK families (III and IV) and from three cytoplasmic-TK families (Syk, Abl, and Jak) on samples from 44 BCR/ABL1-negative and JAK2(V617F)-negative CMPN patients with different clinical phenotypes. Although screening by FISH did not reveal novel chromosomal aberrations, several sequence changes were detected. None of them were frequent events, but we identified a new potential activating mutation in the FERM domain of JAK2(R340Q). None of the germline JAK2(V617F) single-nucleotide polymorphisms detected differed in distribution between patients and control subjects. In summary, data presented here show that these genes are not frequently mutated or rearranged in CMPNs, suggesting that molecular events causing these disorders must be located in other genes.
Enlace permanente: http://hdl.handle.net/10171/7308
Aparece en las colecciones: DA - Ciencias - Genética - Artículos de revista

Ficheros en este registro:
Fichero:  Aranaz-Ormazabal_A new potential oncogenic mutation in the FERM domain_CGC 2009.pdf
Descripción: 
Tamaño:  266,16 kB
Formato:  Adobe PDF
 Visualizar / Abrir 

Los ítems de Dadun están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.