Artículos de revista (TECNUN)
Permanent URI for this collectionhttps://hdl.handle.net/10171/70269
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315 results
Results
- Multidisciplinary analysis of a 750 kW PMSM for marine propulsion including shock loading response.(2020) Prieto-Rocandio, B. (Borja); Satrústegui-de-Legarra, M. (Marco); Elósegui-Simón, I. (Ibón); Gil-Negrete, N. (Nere)This study presents the electromagnetic, thermal and mechanical analysis of a 750 kW, 1200 rpm, 690 V surface permanent magnet motor aimed at marine propulsion (azimuth thruster). Based on a preliminary machine design, key electromagnetic design aspects including magnet demagnetisation and magnet loss reduction by tangential and axial segmentation are assessed. Then, three different cooling solutions are evaluated via computational fluid dynamics simulations combining the use of a water-jacket surrounding the stator, wafters attached to the rotor structure and the addition of an inner fan. Subsequently, the dynamic design analysis method is applied in order to check the machine's response to shock loadings due to underwater explosions. Finally, a machine prototype is successfully manufactured and tested, showing the proper fulfilment of the design requirements.
- Improving the performance of a 1-MW induction machine by optimally shifting from a three-phase to a six-phase machine design by rearranging the coil connections.(2021) Paredes-Puente, J. (Jesús); Prieto-Rocandio, B. (Borja); Satrústegui-de-Legarra, M. (Marco); Elósegui-Simón, I. (Ibón); González, P. (Patxi)It is well known that multiphase machines exhibit the better performance (efficiency, torque density, fault tolerance, etc.) than three-phase machines. From the manufacturing point of view, it is interesting to have the possibility of improving a machine design by just conducting minor changes in the production process. In this regard, six-phase machines emerge as the natural choice to improve a design without modifying the active parts. This article presents an optimal procedure to shift from a three-phase to a six-phase induction motor design by just rearranging the coil connections. By starting from a three-phase winding design, different six-phase winding arrangements are analyzed. A methodology to define all the possible six-phase winding arrangements is presented. Discard criteria based on balanced radial forces and impedances are defined. Afterward, selected winding candidates are compared in terms of analytical calculations and later on, based on finite element (FE) simulations for a 690 V, 1-MW induction machine design. Different possible configurations are evaluated in terms of stator Joule losses, torque ripple, power factor, and electromagnetic efficiency both under healthy and faulted inverter conditions. Finally, a six-phase machine prototype is tested in order to verify the improvement in machine characteristics, thus validating the proposed method.
- On the importance of spiral-flow inflow boundary conditions when using idealized artery geometries in the analysis of liver radioembolization: A parametric study.(2020) Ortega, J. (Julio); Antón-Remírez, R. (Raúl); Ramos-González, J. (Juan Carlos); Rivas-Nieto, A. (Alejandro); Sanchez-Larraona, G. (Gorka); Sangro, B. (Bruno); Bilbao, J.I. (José I.); Aramburu-Montenegro, J. (Jorge)
- Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0.(2019) Heirendt, L. (Laurent); Arreckx, S. (Sylvain); Pfau, Thomas; Mendoza, S.N. (Sebastián N.); Richelle, A. (Anne); Heinken, Almut; Haraldsdóttir, H.S. (Hulda S.); Wachowiak, J. (Jacek); Keating, S.M. (Sarah M.); Vlasov, V. (Vanja); Magnusdóttir, S. (Stefania); Ng, C. Y. (Chiam Yu); Preciat, G. (German); Zagare, A. (Alise); Chan, S.H.J. (Siu H.J.); Aurich, M.K. (Maike K.); Clancy, C.M. (Catherine M.); Modamio, J. (Jennifer); Sauls, J.T. (John T.); Noronha, A. (Alberto); Bordbar, A. (Aarash); Cousins, B. (Benjamin); El Assal, D.C. (Diana C.); Valcárcel-García, L.V. (Luis Vitores); Apaolaza-Emparanza, I.(Iñigo); Ghaderi, S. (Susan); Ahookhosh, M. (Masoud); Ben Guebila, M. (Marouen); Kostromins, A. (Andrejs); Sompairac, N. (Nicolas); Le, H.M. (Hoai M.); Ma, D. (Ding); Sun, Y. (Yuekai); Wang, L. (Lin); Yurkovich, J.T. (James T.); Oliveira, M.A.P. (Miguel A.P.); Vuong, P.T. (Phan T.); El Assal, L.P. (Lemmer P.); Kuperstein, I. (Inna); Zinovyev, A. (Andrei); Hinton, H.S. (H.Scott); Bryant, W.A. (William A.); Aragón-Artacho, F.J. (Francisco J.); Planes-Pedreño, F.J. (Francisco Javier); Stalidzans, E. (Egils); Maass, A. (Alejandro); Vempala, S. (Santosh); Hucka, M. (Michael); Saunders, M.A. (Michael A.); Maranas, C.D. (Costas D.); Lewis, N.E. (Nathan E.); Sauter, T. (Thomas); Palsson, B. O. (Bernhard O.); Thiele, I. (Inés); Fleming, R.M.T. (Ronan M.T.)Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic framework for integrative analysis of experimental molecular systems biology data and quantitative prediction of physicochemically and biochemically feasible phenotypic states. The COBRA Toolbox is a comprehensive desktop software suite of interoperable COBRA methods. It has found widespread application in biology, biomedicine, and biotechnology because its functions can be flexibly combined to implement tailored COBRA protocols for any biochemical network. This protocol is an update to the COBRA Toolbox v.1.0 and v.2.0. Version 3.0 includes new methods for quality-controlled reconstruction, modeling, topological analysis, strain and experimental design, and network visualization, as well as network integration of chemoinformatic, metabolomic, transcriptomic, proteomic, and thermochemical data. New multi-lingual code integration also enables an expansion in COBRA application scope via high-precision, high-performance, and nonlinear numerical optimization solvers for multi-scale, multi-cellular, and reaction kinetic modeling, respectively. This protocol provides an overview of all these new features and can be adapted to generate and analyze constraint-based models in a wide variety of scenarios. The COBRA Toolbox v.3.0 provides an unparalleled depth of COBRA methods.
- Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression(2019) Segovia, C. (Cristina); San-Jose-Eneriz, E. (Edurne); Munera-Maravilla, E. (Ester); Martínez-Fernández, M. (Mónica); Garate, L. (Leire); Miranda, E. (Estibaliz); Vilas-Zornoza, A. (Amaia); Lodewijk, I. (Iris); Rubio, C. (Carolina); Segrelles, C. (Carmen); Valcárcel-García, L.V. (Luis Vitores); Rabal, O. (Obdulia); Casares, N. (Noelia); Bernardini, A. (Alejandra); Suárez-Cabrera, C. (Cristian); Lopez-Calderón, F. (Fernando); Fortes, P. (Puri)Bladder cancer is lethal in its advanced, muscle-invasive phase with very limited therapeutic advances(1,2). Recent molecular characterization has defined new (epi) genetic drivers and potential targets for bladder cancer(3,4). The immune checkpoint inhibitors have shown remarkable efficacy but only in a limited fraction of bladder cancer patients(5-8). Here, we show that high G9a (EHMT2) expression is associated with poor clinical outcome in bladder cancer and that targeting G9a/DNMT methyltransferase activity with a novel inhibitor (CM-272) induces apoptosis and immunogenic cell death. Using an immunocompetent quadruple-knockout (Pten(loxP/loxP); Trp53(loxP/loxP); Rb1(loxP/loxP); Rbl1(-/-)) transgenic mouse model of aggressive metastatic, muscle-invasive bladder cancer, we demonstrate that CM-272 + cisplatin treatment results in statistically significant regression of established tumors and metastases. The antitumor effect is significantly improved when CM-272 is combined with anti-programmed cell death ligand 1, even in the absence of cisplatin. These effects are associated with an endogenous antitumor immune response and immunogenic cell death with the conversion of a cold immune tumor into a hot tumor. Finally, increased G9a expression was associated with resistance to programmed cell death protein 1 inhibition in a cohort of patients with bladder cancer. In summary, these findings support new and promising opportunities for the treatment of bladder cancer using a combination of epigenetic inhibitors and immune checkpoint blockade.
- rMTA: robust metabolic transformation analysis.(2019) Valcárcel-García, L.V. (Luis Vitores); Torrano, V. (Verónica); Tobalina-Segura, L. (Luis); Carracedo, A. (Arkaitz); Planes-Pedreño, F.J. (Francisco Javier)
- Upregulated expression and function of theα4β1 integrin in multiple myeloma cells resistant to bortezomib.(2020) Sevilla-Movilla, S. (Silvia); Arellano-Sánchez, N. (Nohemí); Martínez-Moreno, M. (Mónica); Gajate, C. (Consuelo); Sánchez-Vencells, A. (Anna); Valcárcel-García, L.V. (Luis Vitores); Aguirre-Ena, X. (Xabier); Valeri, A. (Antonio); Martínez-López, J. (Joaquín); Prosper-Cardoso, F. (Felipe); Mollinedo, F. (Faustino); Teixidó, J. (Joaquín)The interaction of multiple myeloma (MM) cells with the bone marrow (BM) microenvironment promotes MM cell retention, survival, and resistance to different anti-MM agents, including proteasome inhibitors (PIs) such as bortezomib (BTZ). The alpha 4 beta 1 integrin is a main adhesion receptor mediating MM cell-stroma interactions and MM cell survival, and its expression and function are downregulated by BTZ, leading to inhibition of cell adhesion-mediated drug resistance (CAM-DR) and MM cell apoptosis. Whether decreased alpha 4 beta 1 expression and activity are maintained or recovered upon development of resistance to BTZ represents an important question, as a potential rescue of alpha 4 beta 1 function could boost MM cell survival and disease progression. Using BTZ-resistant MM cells, we found that they not only rescue their alpha 4 beta 1 expression, but its levels were higher than in parental cells. Increased alpha 4 beta 1 expression in resistant cells correlated with enhanced alpha 4 beta 1-mediated cell lodging in the BM, and with disease progression. BTZ-resistant MM cells displayed enhanced NF-kappa B pathway activation relative to parental counterparts, which contributed to upregulated alpha 4 expression and to alpha 4 beta 1-dependent MM cell adhesion. These data emphasize the upregulation of alpha 4 beta 1 expression and function as a key event during resistance to BTZ in MM, which might indirectly contribute to stabilize this resistance, as stronger MM cell attachment to BM stroma will regain CAM-DR and MM cell growth and survival. Finally, we found a strong correlation between highITGB1(integrin beta 1) expression in MM and poor progression-free survival (PFS) and overall survival (OS) during treatment of MM patients with BTZ and IMIDs, and combination of highITGB1levels and presence of the high-risk genetic factor amp1q causes low PFS and OS. These results unravel a novel prognostic value forITGB1in myeloma.
- Is design of experiments really used? A survey of Basque industries.(2008) Tanco-Rainusso, M. (Martín); Viles-Díez, E. (Elisabeth); Ilzarbe, L. (Laura); Álvarez-Sánchez-Arjona, M.J. (María Jesús)A new survey is presented concerning the knowledge and use of the design of experiments technique (DoE) within industry in the Basque Country, a region recognised throughout Europe for its quality management. The survey was carried out within manufacturing companies, yielding a response rate of 18%. Results show that 94% of companies undertake experimentation; most of them use one-factor-at-a-time strategies, and only 20% of those follow a pre-established statistical methodology. Survey results show that research and development and manufacturing make up 85% of DoE use. Furthermore, results show that lack of knowledge about general statistics is commonplace and only 31% of companies claim to be knowledgeable about DoE. In addition, although Taguchi methods are well known among companies, only 7% apply this method. Despite every effort by specialists in quality and statistics, DoE has yet to be applied as widely as it could and should be.
- Practical applications of design of experiments in the field of engineering: A bibliographical review.(2008) Ilzarbe, L. (Laura); Álvarez-Sánchez-Arjona, M.J. (María Jesús); Viles-Díez, E. (Elisabeth); Tanco-Rainusso, M. (Martín)The design of experiments (DoE) methodology is a technique that has been applied for many years in industry to improve quality. In this study, a summary of 77 cases of practical DoE application in the field of engineering is presented. All of the cases were published in important scientific journals between 2001 and 2005. The type of design that is applied, the size of the experiment, the number of factors that influence the response variable, and the sector of application of the design are analyzed. In addition, the increasing use of these designs over time is demonstrated.
- How is Experimentation Carried Out by Companies? A Survey of Three European Regions.(2008) Tanco-Rainusso, M. (Martín); Viles-Díez, E. (Elisabeth); Ilzarbe, L. (Laura); Álvarez-Sánchez-Arjona, M.J. (María Jesús)A survey was carried out to characterize experimentation in three different European regions: the Baden-Wurttemberg region, The Basque Country and the rest of Spain. Results of the survey show that even though experimentation is a frequent activity, almost 95% of companies conduct experiments; the strategies used to carry them out are primitive. The one-factor-at-a-time strategy is used by 75% of companies far more than the 23%, which apply design of experiments (DoE). Results show that this may be due to the current lack of knowledge of DoE in these regions, where only 33% are familiar with the technique. Finally, the rate of applications of DoE among Six Sigma users is 40%, twice that of non-users, which stands at 19%.