Artículos de revista (Inst. Salud Tropical)
Permanent URI for this collectionhttps://hdl.handle.net/10171/52056
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- The defensive interactions of prominent infectious protozoan parasites: the host's complement system(2022) Muro, A. (Antonio); Ali-Hassanzadeh, M. (Mohammad); Mansouri, R. (Reza); Manzano-Román, R. (Raúl); Nguewa, P.A. (Paul Alain); Rashidi, S. (Sajad)The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites. Different pathogens including parasites have developed sophisticated strategies to defend themselves against complement killing. Some of these strategies include the employment, mimicking or inhibition of host's complement regulatory proteins, leading to complement evasion. Therefore, parasites are proven to use the manipulation of the complement system to assist them during infection and persistence. Herein, we attempt to study the interaction's mechanisms of some prominent infectious protozoan parasites including Plasmodium, Toxoplasma, Trypanosoma, and Leishmania dealing with the complement system. Moreover, several crucial proteins that are expressed, recruited or hijacked by parasites and are involved in the modulation of the host's complement system are selected and their role for efficient complement killing or lysis evasion is discussed. In addition, parasite's complement regulatory proteins appear as plausible therapeutic and vaccine targets in protozoan parasitic infections. Accordingly, we also suggest some perspectives and insights useful in guiding future investigations.
- Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices(2023) Levi, M. (Miriam); Charalampous, P. (Periklis); Yigit, V. (Vahit); Nena, E. (Evangelia); Stevanovic, A. (Aleksandar); Haagsma, J.A. (Juanita A.); Fantke, P. (Peter); Pires, S.M. (Sara M.); Padrón-Monedero, A. (Alicia); Plass, D. (Dietrich); Reina-Ortiz, M. (Miguel); Thygesen, L.C. (Lau Caspar); Gunes, S. (Sezgin); Steiropoulos, P. (Paschalis); Chen-Xu, J. (José); von-der-Lippe, E. (Elena); Unim, B. (Brigid); Sarmiento, R. (Rodrigo); Isola, G. (Gaetano); Santoso, C.M.A. (Cornelia Melinda Adi); AlKerw, A. (Ala’a); Mondello, S. (Stefania); Lauriola, P. (Paolo); Gazzelloni, F. (Federica); Fischer, F. (Florian); Noguer, I. (Isabel); Obradovic, M. (Marija); O'Caoimh, R. (Rónán); Gorasso, V. (Vanessa); Brus, I. (Iris); Pinheiro, V. (Vera); Economou, M. (Mary); Cuschieri, S. (Sarah); Konar, N.M. (Naime Meriç); Kolkhir, P. (Pavel); Milicevic, M.S. (Milena Santric); Arabloo, J. (Jalal); Santos, J.V. (Joao Vasco); Vasic, M. (Milena); Hynds, P. (Paul); Kostoulas, P. (Polychronis); Idavain, J. (Jane); Devleesschauwer, B. (Brecht); Peyroteo, M. (Mariana); Mechili, E.A. (Enkeleint A.); Uysal, H.B. (Hilal Bektas); Chaintoutis, S.C. (Serafeim C.); Chkhaberidze, N. (Nino); Tozija, F. (Fimka); Jakobsen, L.S. (Lea S.); Gissler, M. (Mika); García-González, J.M. (Juan Manuel); Hincapie, C.A. (Cesar A.); Gulmez, H. (Hakan); Niranjan, V. (Vikram); Cilovic-Lagarija, S. (Seila); Corso, B. (Barbara); Bikbov, B. (Boris); Speybroeck, N. (Niko); Muñoz-Laguna, J. (Javier); Ng, E.S.W. (Edmond S. W.); Ilic, I. (Irena); Burazeri, G. (Genc); Freitas, A. (Alberto); Kulimbet, M. (Mukhtar); Majer, M. (Marjeta); Monasta, L. (Lorenzo); Di-Bari, C. (Carlotta); Kabir, Z. (Zubair); Pallari, E. (Elena); Baltazar, A.L. (Ana Lúcia); McDonald, S.A. (Scott A.); Varga, O. (Orsolya); Riva, S. (Silvia); Borrell-Pages, M. (Maria); Nguewa, P.A. (Paul Alain); La-Vecchia, C. (Carlo); Dopelt, K. (Keren); Kamusheva, M. (Maria); Haller, S. (Sebastian); Wyper, G.M.A. (Grant M. A.); Haneef, R. (Romana); Sprügel, M. (Maximilian); Pranjic, N. (Nurka); Schmitt, T. (Tugce); Gkitakou, A. (Artemis); Nola, I.A. (Iskra Alexandra); Assunçao, R. (Ricardo); Ilic, M. (Milena); Emeto, T.I. (Theophilus I.); Vieira, R.J. (Rafael José); Ádám, B. (Balázs)This systematic literature review aimed to provide an overview of the characteristics and methods used in studies applying the disability-adjusted life years (DALY) concept for infectious diseases within European Union (EU)/European Economic Area (EEA)/European Free Trade Association (EFTA) countries and the United Kingdom. Electronic databases and grey literature were searched for articles reporting the assessment of DALY and its components. We considered studies in which researchers performed DALY calculations using primary epidemiological data input sources. We screened 3053 studies of which 2948 were excluded and 105 studies met our inclusion criteria. Of these studies, 22 were multi-country and 83 were single-country studies, of which 46 were from the Netherlands. Food- and water-borne diseases were the most frequently studied infectious diseases. Between 2015 and 2022, the number of burden of infectious disease studies was 1.6 times higher compared to that published between 2000 and 2014. Almost all studies (97%) estimated DALYs based on the incidence- and pathogen-based approach and without social weighting functions; however, there was less methodological consensus with regards to the disability weights and life tables that were applied. The number of burden of infectious disease studies undertaken across Europe has increased over time. Development and use of guidelines will promote performing burden of infectious disease studies and facilitate comparability of the results.
- Mining the proteome of Toxoplasma parasites seeking vaccine and diagnostic candidates(2022) Sánchez-Montejo, J. (Javier); Ali-Hassanzadeh, M. (Mohammad); Bahreini, M.S. (Mohammad Saleh); Karimazar, M. (Mohammadreza); Mansouri, R. (Reza); Manzano-Román, R. (Raúl); Savardashtaki, A. (Amir); Nguewa, P.A. (Paul Alain); Rashidi, S. (Sajad)Simple Summary The One Health concept to toxoplasmosis highlights that the health of humans is closely related to the health of animals and our common environment. Toxoplasmosis outcomes might be severe and fatal in patients with immunodeficiency, diabetes, and pregnant women and infants. Consequently, the development of effective vaccine and diagnostic strategies is urgent for the elimination of this disease. Proteomics analysis has allowed the identification of key proteins that can be utilized in the development of novel disease diagnostics and vaccines. This work presents relevant proteins found in the proteome of the life cycle-specific stages of Toxoplasma parasites. In fact, it brings together the main functionality key proteins from Toxoplasma parasites coming from proteomic approaches that are most likely to be useful in improving the disease management, and critically proposes innovative directions to finally develop promising vaccines and diagnostics tools. Toxoplasma gondii is a pathogenic protozoan parasite that infects the nucleated cells of warm-blooded hosts leading to an infectious zoonotic disease known as toxoplasmosis. The infection outcomes might be severe and fatal in patients with immunodeficiency, diabetes, and pregnant women and infants. The One Health approach to toxoplasmosis highlights that the health of humans is closely related to the health of animals and our common environment. The presence of drug resistance and side effects, the further improvement of sensitivity and specificity of serodiagnostic tools and the potentiality of vaccine candidates to induce the host immune response are considered as justifiable reasons for the identification of novel targets for the better management of toxoplasmosis. Thus, the identification of new critical proteins in the proteome of Toxoplasma parasites can also be helpful in designing and test more effective drugs, vaccines, and diagnostic tools. Accordingly, in this study we present important proteins found in the proteome of the life cycle-specific stages of Toxoplasma parasites that are potential diagnostic or vaccine candidates. The current study might help to understand the complexity of these parasites and provide a possible source of strategies and biomolecules that can be further evaluated in the pathobiology of Toxoplasma parasites and for diagnostics and vaccine trials against this disease.