Lucena, F. (Felipe)

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    Enterococcal bloodstream infection. Design and validation of a mortality prediction rule
    (John Wiley & Sons Ltd, 2016) Landecho, M.F. (Manuel F.); Lucena, F. (Felipe); Huerta, A. (Ana); Alegre, F. (Félix); Pérez-García, A. (Alejandra); Conde-Estevez, D. (David); Pozo, J.L. (José Luis) del; Gómez, J. (J.); Mauleón, E. (E.); Beunza, J.J. (Juan José); Grau, S. (Santiago); Terradas-Robledo, R. (Roser); Gea, A. (Alfredo)
    Background: To develop a prediction rule to describe the risk of death as a result of enterococcal bloodstream infection. Methods: A prediction rule was developed by analysing data collected from 122 patients diagnosed with entero- coccal BSI admitted to the Clınica Universidad de Navarra (Pamplona, Spain); and validated by confirming its accuracy with the data of an external population (Hospital del Mar, Barcelona). Results: According to this model, independent sig- nificant predictors for the risk of death were being diabetic, have received appro- priate treatment, severe prognosis of the underlying diseases, have renal failure, received solid organ transplant, malignancy, source of the bloodstream infection and be immunosuppressed. The prediction rule showed a very good calibration (Hosmer–Lemeshow statistic, P = 0.93) and discrimination for both training and testing sets (area under ROC curve = 0.84 and 0.83 respectively). Conclusions: The predictive rule was able to predict risk of death as a result of enterococcal bloodstream infection as well as to identify patients, who being below the thresh- old value, will have a low risk of death with a negative predictive value of 96%.