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Serum levels of S-100 protein are directly proportional to the size, number, thickness and degree of cellularity of congenital melanocytic nevi
(Elsevier, 2023) López-Gutiérrez, J.C. (Juan Carlos); Tomás-Velázquez, A. (Alejandra); Andrés, E.M. (Eva M.); Reyes, M. (Miguel); Salgado, C.M. (Claudia M.); Ceballos-Rodríguez, C. (Carmen); Triana, P. (Paloma); Hervas-Stubbs, S. (Sandra); Reina, G. (Gabriel); Andrea, C.E. (Carlos Eduardo) de; Basu, D. (Dipanjan); Redondo-Bellón, P. (Pedro)
To the Editor: Some patients with congenital melanocytic nevi (CMN) present progressive growth and thickening, extracutaneous involvement (neurocutaneous melanocytosis, NCM) or neoplastic transformation (melanoma); and others remain stable or even regress. There are no markers to assess progression or follow-up. Recently, we found S-100, a protein which acts on cell differentiation and proliferation, elevated in CMN.1 S-100 is a ligand of the RAGE pathway (related to the MAPK-pathway), and low serum levels of soluble-RAGE were related to poor survival in melanoma.2 Also SOX10, expressed in melanocytes with high specificity, is useful in detection, prognosis and treatment assessment of melanoma.3 We explored if S-100, RAGE and SOX10 serum levels vary in children’s CMN and assessed clinical or pathological correlations.