Soler, M. (M.)

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    Estudio de la infección asociada a catéter intravascular durante el año 1998 en la Clínica Universitaria de Navarra at the University Clinic of Navarra
    (Universidad de Navarra, 2001) Leiva, J. (José); Lecaroz, M.C. (María Concepción); Pozo, J.L. (José Luis) del; Soler, M. (M.); Hernaez, S. (S.); Lamata, M. (M.)
    Purpose: To study the intravascular catheter related infections (CRI) since January of 1998 to January of 1999 in our hospital. Methods: We studied 540 catheter tips using a modified combination of the cuantitative method of Cleri and the semicuantitative method of Maki. The catheters were classified into two groups according to the presence or absence of criteria for CRI. Results: 74.5% of the retired catheters because of infection suspice did not satisfied criteria for CRI. 44.7% of the patients with criteria suffered a catheter-related bacteriemia while just 1.7% of the patients without criteria suffered a bacteriemia. The most common isolated microorganisms were coagulase-negative Staphylococci, Corynebacterium species and S. aureus. Discussion and Conclusions: At least, 74.5% of the patients with a suspice of catheter related infection could undergo a non invasive diagnosis procedure that would have showed that the catheter was not infected.
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    B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation
    (Springer, 2020) Subirana-Granés, M. (Marc); Javierre, B.M. (B. M.); Martinez-Climent, J.A. (José Ángel); Soler, M. (M.); Costa, A. (Alberto); Piñeyro, D. (David); Raurell-Vila, H. (Helena); Esteller, M. (Manel); Pasquali, L. (Lorenzo)
    Hematopoiesis is a highly regulated process that, starting from hematopoietic stem cells (HSCs) with self-renewal capacity in the adult human bone marrow, is able to generate all different types of mature blood cells. The classical view of hematopoiesis defines binary branching points from these HSCs that segregate lineages and direct differentiation to terminally differentiated functional cell types [1]. However, the described hierarchical model can be complemented with the emerging data that suggest the existence of hematopoietic stem and progenitor cells with a continuum of transitory differentiation stages, including cells with early lineage priming that generate distinct blood cell types according to the physiological or pathological environment [2].