Cuvillo, A. (A.) del

Filtering

2009 - 200912010 - 20111

Settings

Author search.filters.isAuthorOfPublication.081a7cb2-2ca3-43ce-8c0a-d102d6470e70

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Molecular diagnosis in Allergology: application of the microarray tecnique
    (Esmon, 2009) Sastre, J. (Joaquín); Davila, I. (I.); Mullol, J. (J.); Jauregui, I. (I.); Montoro, J. (J.); Sanz, M.L. (María Luisa); Ferrer-Cardona, M. (Marta); Valero-Santiago, A. (Antonio); Cuvillo, A. (A.) del
    Recombinant and purified allergens are currently available for determining specific IgE targeted to different allergenic components. In this way it is possible to diagnose the sensitization profile of each individual patient. The microarray technique makes it possible to determine specific IgE against multiple allergens simultaneously in one same patient, with a minimum amount of serum, and even allows the determination of IgG and IgM against the same allergens in one same serum sample. Microarray procedures are being developed not only for the determination of antibodies but also for cell activation tests. In addition, microarray technology will help explain cross-reactions, and will facilitate the evaluation of subjects in which skin tests cannot be performed. These techniques will allow a great step forward in the development of immunotherapy specifically targeted to the sensitizations found in each individual patient, yielding especially hypoallergenic forms of great immunogenic capacity, and thus improving the safety and efficacy of immunotherapy. Lastly, microarrays will improve our understanding of the physiopathology of allergic diseases.
  • Thumbnail Image
    Effect of antihistamine up-dosing in chronic urticaria
    (ESMON Publicidad, 2011) Sastre, J. (Joaquín); Davila, I. (I.); Bartra, J. (Joan); Mullol, J. (J.); Jauregui, I. (I.); Montoro, J. (J.); Ferrer-Cardona, M. (Marta); Valero-Santiago, A. (Antonio); Cuvillo, A. (A.) del
    Chronic urticaria has an important impact upon patient quality of life, and no treatment has yet been developed capable of effectively controlling the disease. The most recent guidelines recommend the use of non-sedating antihistamines at high doses as second-step therapy before resorting to other treatments. The present review examines the studies published to date on the use of H1 antihistamines at doses higher than those indicated as therapeutic doses in chronic urticaria. Most of the studies report no significant differences among the studied doses – only a tendency towards increased response on elevating the dose.There are no clinically well designed, randomized double-blind trials comparing efficacy between therapeutic doses and doses higher than those indicated in the corresponding Summary of Product Characteristics. Likewise, there are insufficient data to conduct a meta-analysis and thus classify the degree of evidence of the few available studies, which moreover present contradictory results. At present, the prescription of high-dose H1 antihistamines is based only on experts opinion. However, considering the high safety profile of these drugs, it would be a good option to evaluate their efficacy at high doses, before moving on to other therapeutic steps.