Cabezudo-García, P. (Pablo)

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    COVID-19 prevalence and mortality in people with epilepsy: A nation-wide multicenter study
    (Elsevier, 2021) Sánchez-Larsen, Á. (Álvaro); Conde-Blanco, E. (Estefanía); Viloria-Alebesque, A. (Alejandro); Sánchez-Vizcaína Buendía, C. (Cristina); Espinosa-Oltra, T. (Tatiana); Álvarez-Noval, A. (Amanda); Aledo-Serrano, A. (Angel); Martín-García, R. (Raquel); Ramos-Araque, M.E. (María E.); Campos, D. (Dulce); Valle-Peñacoba, G. (Gonzálo); Sierra-Gómez, A. (Alicia); Ceballos-Cerrajería, P. (Pablo de); Agundez-Sarasola, M. (Marta); Khawaja, M. (Mariam); Hampel, K.G. (Kevin G.); Serra-Martínez, M. (María); Arbós-Barber, C. (Clara); Gomez-Ibañez, A. (Asier); Villino, R. (Rafael); Cabezudo-García, P. (Pablo); Rodríguez-Lavado, I. (Ignacio); Prícipe, A. (Alessandro); Sopelana-Garay, D. (David)
    Background To assess the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE) and evaluate seizure control in PWE during and after COVID-19. Methods Retrospective, observational, multicenter study conducted in 14 hospitals. Medical records of randomly selected PWE followed at neurology outpatient clinics were reviewed. Proportion of PWE with a positive test for SARS-CoV-2 during 2020 was calculated. Risk factors associated with COVID-19 and its morbimortality were evaluated. Results 2751 PWE were included, mean age 48.8 years (18–99), 72.4% had focal epilepsy, and 35% were drug-refractory. COVID-19 prevalence in PWE was 5.53%, while in the Spanish population was 4.26%. Proportion of admissions to hospital, ICU, and deaths in PWE were 17.1%, 2%, and 4.61% of COVID-19 cases, while in Spanish population were 10.81%, 0.95%, and 2.57%, respectively. A severe form of COVID-19 occurred in 11.8%; dyslipidemia, institutionalization at long-term care facilities, intellectual disability, and older age were associated risk factors. Older age, hypertension, dyslipidemia, cardiac disease, and institutionalization were associated with mortality from COVID-19. Seizure control was stable in 90.1% of PWE during acute COVID-19, while 8.6% reported an increase in seizure frequency. During post-COVID-19 follow-up, 4.6% reported seizure control worsening. Conclusions COVID-19 was moderately prevalent in PWE. One out of 5 patients required medical attention and 4.6% died due to COVID-19. Older age, dyslipidemia, institutionalization, and intellectual disability were significant risk factors associated with severe COVID-19. Seizure control remained stable during COVID-19 and throughout long-term follow-up in most PWE who contracted the infection.