Dolei, A. (Antonina)
- Publications
- item.page.relationships.isContributorAdvisorOfPublication
- item.page.relationships.isContributorOfPublication
Search Results
Now showing 1 - 1 of 1
- Multiple sclerosis and HERV-W/MSRV: A multicentric study(Master Publishing Group, 2007) Granieri, E. (Enrico); Fainardi, E. (Enrico); Arru, G. (Giannina); Link, H. (Hans); Sotgiu, S. (Stefano); Fernandez, M. (Miriam); Fois, M.L. (Maria Laura); Villoslada, P. (Pablo); Dolei, A. (Antonina); Castellazzi, M. (Massimiliano); Sanna, A. (Alessandra); Mameli, G. (Giuseppe); Astone, V. (Vito); Serra, C. (Caterina); Rosati, G. (Giulio); Huang, Y.M. (Yu-Min)We designed a large multicentric study to analyse the presence of MSRV particles in blood and CSF of a large cohort of patients and controls from different European areas. 149 MS patients and 153 neurological and healthy controls were selected from Sardinia, Spain, Northern-Italy and Sweden. To avoid biological and inter-assay variability MSRV was detected within a single laboratory through nested and real-time PCR assays specific for pol and env genes. MSRV detection in blood and CSF of MS patients and controls in populations of different ethnicity gave significant differences (p<0.05 compared to neurological controls and <0.001 compared to healthy controls). The presence and viral load of MSRV are significantly associated with MS as compared to neurological and healthy controls in all ethnic groups.