Bories, C. (C.)
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- In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188(American Society for Microbiology, 2000) Bories, C. (C.); Espuelas, S. (Socorro); Barratt, G. (G.); Legrand, P. (P.); Loiseau, P.M. (P.M.); Irache, J.M. (Juan Manuel)A micellar formulation of amphotericin B (AmB) solubilized with poloxamer 188 was evaluated against an AmB Leishmania donovani-resistant line. A concave isobologram showed a synergistic effect of this association against promastigotes. This result was confirmed with amastigotes since the 50% effective concentration of the new formulation was 100 times less than that of the control AmB formulation.