Pérez-Cuenca, I. (Isabel)
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- Molecular profiling of immunoglobulin heavychain gene rearrangements unveils new potential prognostic markers for multiple myeloma patients(2020) Gonzalez-Calle, V. (Veronica); Martínez-López, J. (Joaquín); Garcia-Alvarez, M. (María); Gonzalez, M. (Marcos); Gironella, M. (Mercedes); Bladé, J. (Joan); Prieto-Conde, M.I. (María Isabel); Sarasquete, M.E. (María E.); García-Sanz, R. (Ramón); Alcoceba, M. (Miguel); Medina, A. (Alejandro); Mateos, M.V. (María Victoria); Hernandez, M.T. (Miguel Teodoro); Balanzategui, A. (Ana); Puig, N. (Noemí); Barrio, S. (Santiago); Pérez-Cuenca, I. (Isabel); Lahuerta-Vargas, J.J. (Juan José); Gutierrez, N.C. (Norma C.); Escalante, L.F. (Luis Fernando); Oriol, A. (Albert); Sureda-Balari, A. M. (Anna Maria); Chillón, M.C. (María del Carmen); Calasanz-Abinzano, M.J. (Maria Jose); San-Miguel, J.F. (Jesús F.); Jiménez, C. (Cristina)Multiple myeloma is a heterogeneous disease whose pathogenesis has not been completely elucidated. Although B-cell receptors play a crucial role in myeloma pathogenesis, the impact of clonal immunoglobulin heavy-chain features in the outcome has not been extensively explored. Here we present the characterization of complete heavychain gene rearrangements in 413 myeloma patients treated in Spanish trials, including 113 patients characterized by next-generation sequencing. Compared to the normal B-cell repertoire, gene selection was biased in myeloma, with significant overrepresentation of IGHV3, IGHD2 and IGHD3, as well as IGHJ4 gene groups. Hypermutation was high in our patients (median: 8.8%). Interestingly, regarding patients who are not candidates for transplantation, a high hypermutation rate (≥7%) and the use of IGHD2 and IGHD3 groups were associated with improved prognostic features and longer survival rates in the univariate analyses. Multivariate analysis revealed prolonged progression-free survival rates for patients using IGHD2/IGHD3 groups (HR: 0.552, 95% CI: 0.361−0.845, p = 0.006), as well as prolonged overall survival rates for patients with hypermutation ≥7% (HR: 0.291, 95% CI: 0.137−0.618, p = 0.001). Our results provide new insights into the molecular characterization of multiple myeloma, highlighting the need to evaluate some of these clonal rearrangement characteristics as new potential prognostic markers.
- Francisco de Quevedo en su biblioteca “con pocos pero doctos libros juntos”(Servicio de Publicaciones de la Universidad de Navarra, 2023) Pérez-Cuenca, I. (Isabel)
- Las lecturas de Quevedo a la luz de algunos impresos de su biblioteca(GRISO-Universidad de Navarra, 2003) Pérez-Cuenca, I. (Isabel)En este trabajo se realiza un primer acercamiento a la configuración del catálogo de la posible biblioteca a la que tuvo acceso Quevedo (ya fuera en ejemplares suyos o del Duque de Medinaceli). La reconstrucción de esta «biblioteca imaginaria» se realiza a partir de los índices de libros del Monasterio de San Martín de Madrid. Por ello, se ha procedido a una primera cala en dichos índices con la finalidad de identificar ediciones de autores leídos y citados por Quevedo: Arias Montano, Botero, Lipsio, Petrarca, padre Mariana, entre otros. También se presenta el hallazgo de una obra de Carpentier propiedad de Quevedo, que se añade a los más de 25 impresos ya conocidos de su biblioteca. The present work constitutes a preliminary approach to the possible catalogue of a potential library that could have been accessible to Quevedo, either through their own books or through those of the Duke of Medinaceli. The reconstruction of this «imaginary library» is based on the indexes of the library of the Monasterio de San Martín, Madrid. A first screening of those indexes have been performed in order to identify printed books which Quevedo read and cited from, among others, Arias Montano, Botero, Lipsio, Petrarca and Mariana. A couple of works from Carpentier have been also identified as being property of Quevedo. These works must now be added to those already known printed books from his library, more than 25 pieces of work until now
- Esbozos de retratos en las cartas de Francisco de Quevedo(Servicio de Publicaciones de la Universidad de Navarra, 2018) Pérez-Cuenca, I. (Isabel)Reading Quevedo’s correspondence gives us the opportunity of looking at his literary production from a new perspective, which completes and helps defining its many different facets. The point of departure in this occasion is his letters. Based on them we study the portraits of persons represented there. Their presence in the letters aims at very different objectives, depending on the person depicted and the addressee of the letter. Very often, these portraits are only sketches, made out of a few strokes, which need an intelligent reading by the addressee to be fully understood. This can explain why some of these portraits seem to us dark and too short: probably, they are supposed to be clear only to the person to whom they are addressed.
- Algunos casos de atribuidos y apócrifos en las ediciones de la poesía de Quevedo(GRISO-Universidad de Navarra, 2000) Pérez-Cuenca, I. (Isabel)En este artículo se ha pretendido realizar una revisión de los textos apócrifos y atribuidos que han sido recogidos en las ediciones de la poesía completa de Quevedo. Para ello se ha reunido la bibliografía existente y consultado varios testimonios manuscritos, con la finalidad de analizar y valorar los textos espurios o de dudosa autoría adjudicados al escritor madrileño. In this article, it has been pretended to make a review of the apocryphal and attributed texts that have been recollected in the complete poetry edition of Quevedo. For that purpose, the existent bibliography has been reunited as well as consulted some manuscript testimonies to analyse and validate the spurious and doubtful authored texts attributed to the Madrilenian writer.
- Reseña de Chevalier, M., Quevedo y su tiempo: la agudeza verbal, Barcelona, Crítica, 1992(GRISO-Universidad de Navarra, 1997) Pérez-Cuenca, I. (Isabel)