Reyes, M. (Miguel)
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- Development of an activity disease score in patients with uveitis (UVEDAI)(Springer Verlag, 2017) Fernández-Espartero, C. (Cruz); Díaz-Valle, D. (David); Reyes, M. (Miguel); Díaz-Valle, T. (Teresa); Méndez‐Fernández, R. (Rosalía); Beltrán-Catalán, E. (Emma); Pato, E. (Esperanza); Martín‐Martínez, M. A. (María Auxiliadora); Esteban, M. (Mar); Sánchez-Alonso, F. (Fernando); Muñoz-Fernández, S. (Santiago); Carrasco-Gimeno, J.M. (José Miguel); Valls, E. (Elia); Hernández-Garfella, M. (Marisa); Cordero-Coma, M. (Miguel); Castelló, A. (Adela); Blanco, R. (Ricardo); Pelegrín, L. (Laura); Martínez-Costa, L. (Lucía); Fonollosa, A. (Alex); Hernández, M.V. (María Victoria); Francisco, F. (Félix)To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases.
- Serum levels of S-100 protein are directly proportional to the size, number, thickness and degree of cellularity of congenital melanocytic nevi(Elsevier, 2023) López-Gutiérrez, J.C. (Juan Carlos); Tomás-Velázquez, A. (Alejandra); Andrés, E.M. (Eva M.); Reyes, M. (Miguel); Salgado, C.M. (Claudia M.); Ceballos-Rodríguez, C. (Carmen); Triana, P. (Paloma); Hervas-Stubbs, S. (Sandra); Reina, G. (Gabriel); Andrea, C.E. (Carlos Eduardo) de; Basu, D. (Dipanjan); Redondo-Bellón, P. (Pedro)To the Editor: Some patients with congenital melanocytic nevi (CMN) present progressive growth and thickening, extracutaneous involvement (neurocutaneous melanocytosis, NCM) or neoplastic transformation (melanoma); and others remain stable or even regress. There are no markers to assess progression or follow-up. Recently, we found S-100, a protein which acts on cell differentiation and proliferation, elevated in CMN.1 S-100 is a ligand of the RAGE pathway (related to the MAPK-pathway), and low serum levels of soluble-RAGE were related to poor survival in melanoma.2 Also SOX10, expressed in melanocytes with high specificity, is useful in detection, prognosis and treatment assessment of melanoma.3 We explored if S-100, RAGE and SOX10 serum levels vary in children’s CMN and assessed clinical or pathological correlations.