Conchillo, F. (F.)
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- Tratamiento de la cirrosis biliar primaria con ácido ursodesoxicólico. Resultados a corto y medio plazo y relación con el estudio de la enfermedad(The Spanish Society of Digestive Pathology, 1991) Conchillo, F. (F.); Garcia-Villarreal, L. (Luis); Prieto, J. (Jesús); Macias, E. (Elena); Garcia-Gonzalez, N. (Nicolás); Quiroga, J. (Jorge); Zozaya, J.M. (José Manuel)We present the results of the treatment with ursodeoxycholic acid (UDCA, 7-9 mg/kg body weight daily) of 17 patients with primary biliary cirrhosis (8 in stages I-II; 9 in stages III-IV). At two months the mean values of alkaline phosphatase, gammaglutamiltranspeptidase, alanine and aspartate aminotransferase were reduced (p less than 0.001, p less than 0.001, p less than 0.01 and p less than 0.01 respectively). This improvement persisted without increase during the first year. At two months the total bilirubin value was reduced (p less than 0.01) associated with a reduction in the conjugated fraction (p less than 0.05). Cholesterol and gammaglobulin mean values also decreased at two months (p less than 0.05). We found no changes in IgM levels and antimitochondrial antibody titers. The improvement was similar in both groups (early I-II and advanced III-IV stages) and the treatment showed no undesirable effects either in early or advanced stages. Almost all the patients with pruritus (6 out of 7) improved with the treatment and the use of cholestyramine was reduced in all
- Sucralfato(Universidad de Navarra, 1982) Sanchez, L. (L.); Conchillo, F. (F.); Muñoz-Navas, M. (Miguel); Zozaya, J.M. (José Manuel)
- La actividad de la nefrona en la cirrosis hepática(The Spanish Society of Digestive Pathology, 1970) Arroyo, J.L. (José L.); Conchillo, F. (F.); Purroy, A. (A.); Ortiz-de-Landazuri, E. (E.); Bueno, J. (J.)
- Colitis colágena: estudio clinicopatológico de seis nuevos casos(The Spanish Society of Digestive Pathology, 1993) Muñoz, M. (Manuel); Angós, R. (Ramón); Conchillo, F. (F.); Idoate, M.A. (Miguel Ángel); Zozaya, J.M. (José Manuel)Collagenous colitis (CC) is a newly recognized entity characterized clinically by chronic watery diarrhoea and pathologically by epithelial inflammatory injury and the presence of a thickened collagen band beneath the surface epithelium of the colon. Clinical and pathological data of six patients (5 women and 1 man, mean age 54 years) with this diagnosis have been reviewed. Chronic watery diarrhoea was the main sympton in all cases, ranging from 2 to 12 bowel movements a day (mean ± SD, 5,5 ± 2,3) lasting from 8 months to 19 years (mean ± SD, 6,6 ± 5,9 years). Laboratory, barium and endoscopic studies showed unspecific findings. Rheumatic and thyroid diseases as well as drug allergies were found in five cases. The cause of collagenous colitis and the mechanism of diarrhoea remains undefined, being the inflammatory and autoinmune hypothesis the most likely. Diagnosis was made by multiple rectal and colonic biopsies. Pathologic findings characteristic of CC were more prominent in proximal than in distal colonic specimens. Different treatments were applied and diverse clinic responses were obtained. A review of the literature is made.
- La macrobiopsia endoscópica en el diagnóstico de la enfermedad de Menetrier(Elsevier España, 1984) Sanchez, L. (L.); Conchillo, F. (F.); Muñoz-Navas, M. (Miguel); Ruiz, R. (R.); Zozaya, J.M. (José Manuel); Marigil, M.A. (M.A.)For the anatompathological diagnosis of Menetrier's disease to be made, it is necessary to have a biopsy covering the entire thickness of the mucosa. Until a few years ago, to obtain this it was necessary to resort to a surgical biopsy performed during the course of a laparotomy. We present our experience in 6 patients suffering from this disease, in whom the conventional biopsies taken during the course of a gastroscopy, did not enable us to make the anatomopathological diagnosis of the said entity. The performing during the same exploration of an endoscopic macrobiopsy taken with a polypectomy loop provided us with the diagnosis. The simplicity, harmlessness and abscence of complications as well as its diagnostic efficiency, along with the fact that a laparotomy is avoided, mean that this technique is vitally important in the diagnosis of Menetrier's disease.