Sánchez-Hernández, M.V. (Miguel Vicente)

Filtering

20201

Settings

Author search.filters.isAuthorOfPublication.2b97e904-911e-4586-9452-fd98e312e0eb

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study
    (Elsevier, 2020) Martínez, C. (Carmen); Santos, A. (Arnoldo); Pérez-Calvo, C. (César); Fernandez-Aviles, F. (Francisco); Soria, B. (Bernat); Hernández-Blasco, L.M. (Luis M.); Soria-Juan, B. (Bárbara); Pozo, J.L. (José Luis) del; Sánchez-Hernández, M.V. (Miguel Vicente); Sagredo, V. (Víctor); Monedero, P. (Pablo); Andreu, E.J. (Enrique José); Lopez-Parra, M. (Miriam); Álvarez-Avello, J.M. (J. M.); Garcia-Olmos, D. (Damián); Sempere, J.M. (José M.); Fernández-Santos, M.E. (María Eugenia); Guerrero, J.E. (José Eugenio); Andreu, E. (Etelvina); Zapata, A. (Agustín); Prosper-Cardoso, F. (Felipe); García-Arranz, M. (Mariano); Moraleda, J. M. (José M.); Sanchez-Guijo, F.M. (Fermín M.)
    Background: Identification of effective treatments in severe cases of COVID-19 requiring mechanical ventilation represents an unmet medical need. Our aim was to determine whether the administration of adiposetissue derived mesenchymal stromal cells (AT-MSC) is safe and potentially useful in these patients. Methods: Thirteen COVID-19 adult patients under invasive mechanical ventilation who had received previous antiviral and/or anti-inflammatory treatments (including steroids, lopinavir/ritonavir, hydroxychloroquine and/or tocilizumab, among others) were treated with allogeneic AT-MSC. Ten patients received two doses, with the second dose administered a median of 3 days (interquartile range-IQR- 1 day) after the first one. Two patients received a single dose and another patient received 3 doses. Median number of cells per dose was 0.98 £ 106 (IQR 0.50 £ 106 ) AT-MSC/kg of recipient’s body weight. Potential adverse effects related to cell infusion and clinical outcome were assessed. Additional parameters analyzed included changes in imaging, analytical and inflammatory parameters.