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Protection from Staphylococcus aureus mastitis associated with poly-N-acetyl beta-1,6 glucosamine specific antibody production using biofilm-embedded bacteria
(Elsevier, 2009) Lasa, I. (Íñigo); Maira-Litran, T. (T.); Solano, C. (C.); Penades, J. (J.); Marco, J. (J.); Andres, D. (D.) de; Amorena, B. (Beatriz); Prenafeta, A. (A.); Costa, L. (L.); Pier, G.B. (G.B.); Jimenez-Barbero, J. (J.); Irache, J.M. (Juan Manuel); Perez-Calvo, M.M. (M.M.); Rota, C. (C.); Grillo, M.J. (María Jesús); Valle, J. (Jaione)
Staphylococcus aureus vaccines based on bacterins surrounded by slime, surface polysaccharides coupled to protein carriers and polysaccharides embedded in liposomes administered together with non-biofilm bacterins confer protection against mastitis. However, it remains unknown whether protective antibodies are directed to slime-associated known exopolysaccharides and could be produced in the absence of bacterin immunizations. Here, a sheep mastitis vaccination study was carried out using bacterins, crude bacterial extracts or a purified exopolysaccharide from biofilm