Modesto, C. (C.)
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- Adhesive capsulitis. Is it possible in childhood?(Informa Healthcare, 1995) Aquerreta, D. (Dámaso); Crespo, E. (Eduardo); Modesto, C. (C.); Villas-Tome, C. (Carlos)Adhesive capsulitis affecting shoulders has been extensively studied by orthopedic surgeons, but few reports have been published on this condition when it affects other joints (hips, ankles). To our knowledge no pediatric cases have been reported. As its treatment requires prolonged physiotherapy and sometimes manipulation, a correct diagnosis is essential. We would like to emphasize the importance of having this condition in mind when one is regarding a differential diagnosis, also in children.
- Screening of the human tumor necrosis factor-alpha (TNF-α) gene promoter polymorphisms by PCR–DGGE analysis(Elsevier, 1999) Patiño-García, A. (Ana); Sotillo, E. (Elena); Sierrasesumaga, L. (Luis); Modesto, C. (C.)We have designed a new PCR-DGGE technique that enables detection of base changes in the TNF-alpha gene promoter. Screening of 130 samples from Spanish children has shown that this technique accurately detects the altered band patterns induced by the presence of the polymorphisms at positions -376, -308, -238 and -163 of the promoter sequence. Although further analysis are needed to fully characterise the alterations detected, we believe that this PCR-DGGE technique is a rapid and sensitive first approach to the genetic characterisation of the TNF-alpha promoter