Fernandez, O. (O.)

Filtering

20041

Settings

Author search.filters.isAuthorOfPublication.547a250a-95c8-4e31-9d6e-3c3ba5c069e5

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    A single prior course of BCNU-cisplatin chemotherapy has a significant deleterious effect on mobilization kinetics of otherwise untreated patients
    (Springer Nature, 2004) Pérez-Calvo, J. (J.); Martin-Algarra, S. (Salvador); Aristu-Mendioroz, J.J. (José Javier); Rifon, J. J. (Jose J.); Rocha, E. (Eduardo); Fernandez, O. (O.); Aramendia, J.M. (José Manuel); Bendandi, M. (Maurizio); Prosper-Cardoso, F. (Felipe)
    Extensive prior treatment with cytotoxic agents is associated with impaired mobilization of hematopoietic cells. To assess the effect of a single course of standarddose chemotherapy (CT), we compared the results of filgrastim-induced mobilization among two sequential groups of grade III–IV malignant glioma patients included in a hematopoietic transplantation program. The first group (21 patients) had never been treated with CT until 2 days after surgery, when they received a course of 100 mg/m2 BCNU (IV) and 100 mg intracarotid cisplatin for cytoreduction (not for mobilization). At 1 month after this CT, they were mobilized with 12 lg/kg filgrastim. The second group (22 patients) was mobilized with the same dose of filgrastim directly after the surgery, without having ever received any prior CT. The blood level of CD34 þ cells was significantly lower in the CT-treated patients, both on the fourth day of filgrastim (15 vs 36 cells 106 /l; P ¼ 0.01) and on the fifth (25 vs 58 cells 106 /l; P ¼ 0.003), as it was the number of CD34 þ cells collected per apheresis (1.3 vs 3.5 106 /l; Po0.0005). The toxic effect of a single course of BCNUcisplatin CT led to significant impairment of the filgrastim-induced mobilization response.