Pinazo-Duran, M.D. (M. Dolores)

Filtering

2013 - 20203

Settings

Author search.filters.isAuthorOfPublication.5719b5c3-5477-4039-b12a-febe05813715

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Do nutritional supplements have a role in age macular degeneration prevention?
    (Hindawi Publishing Corporation, 2014) Salas, A. (Anna); Diaz-Llopis, M. (Manuel); Gomez-Ulla, F. (Francisco); Arias, L. (Luis); Lopez-Galvez, M.I. (María Isabel); Garcia-Medina, J.J. (José Javier); Araiz, J. (Javier); Garcia-Layana, A. (Alfredo); Zapata, M. (Miguel); Gallego-Pinazo, R. (Roberto); Pinazo-Duran, M.D. (M. Dolores); Casaroli-Marano, R. (Ricardo); Manzanas, L. (Lucía)
    Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids ( ω -3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and ω -3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of ω -3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and ω -3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD.
  • Thumbnail Image
    Computational analysis of clinical and molecular markers and new theranostic possibilities in primary open-angle glaucoma
    (MDPI AG, 2020) Moreno-Montañes, J. (Javier); Garcia-Medina, J.J. (José Javier); Valero-Vello, M. (Mar); Abellán-Abenza, J. (Javier); Sanz-González, S.M. (Silvia M.); Bolarín, J.M. (José M.); Zanón-Moreno, V. (Vicente); Pinazo-Duran, M.D. (M. Dolores)
    Primary open-angle glaucoma (POAG) is a paramount cause of irreversible visual disability worldwide. We focus on identifying clinical and molecular facts that may help elucidating the pathogenic mechanisms of the disease. By using ophthalmological approaches (biomicroscopy, ocular fundus, optical coherence tomography, and perimetry) and experimental tests (enzyme-linked immunosorbent assay (ELISA), high performance liquid chromatography (HPLC), and Western blot/immunoblotting) directed to evaluate the oxidative stress, inflammation, apoptosis, and neurodegeneration processes, we gather information to build a network of data to perform a computational bioinformatics analysis. Our results showed strong interaction of the above players and its downstream effectors in POAG pathogenesis. In conclusion, specific risk factors were identified, and molecules involved in multiple pathways were found in relation to anterior and posterior eye segment glaucoma changes, pointing to new theranostic challenges for better managing POAG progression.
  • Thumbnail Image
    Smoking and age-related macular degeneration: review and update
    (Hindawi, 2013) Diaz-Llopis, M. (Manuel); Gomez-Ulla, F. (Francisco); Dolz-Marco, R. (Rosa); Garcia-Medina, J.J. (José Javier); Arevalo, J.F. (J. Fernando); Pons-Vazquez, S. (Sheila); Velilla, S. (Sara); Garcia-Layana, A. (Alfredo); Gallego-Pinazo, R. (Roberto); Pinazo-Duran, M.D. (M. Dolores)
    Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evaluating the association between smoking and AMD, the mechanisms through which smoking induces damage to the chorioretinal tissues, and the relevance of advising patients to quit smoking for their visual health.