Monreal, M. (M.)
- Publications
- item.page.relationships.isContributorAdvisorOfPublication
- item.page.relationships.isContributorOfPublication
4 results
Search Results
Now showing 1 - 4 of 4
- Tratamiento con octreotide (SMS 201-995) en un caso de tumor carcinoide intestinal(Elsevier España, 1991) Llorente, I. (Ignacio); Goñi, F. (F.); Goñi, M.J. (M. J.); Gonzalez, A. (A.); Moncada, E. (Emilio); Monreal, M. (M.); Yoldi, A. (A.); Oleaga, A. (A.)Over the past few years the usefulness of some somatostatin's analogues in the treatment of intestinal tract endocrine tumors has been demonstrated. Notwithstanding, the results obtained are variable. The case of a carcinoid tumor with a hepatic metastasis is presented and its clinical as well as its biochemical and its morphological results are evaluated after treatment with octreotide over a seven months period. It is important to highlight the great clinical improvement obtained at the beginning of treatment. Treatment was not effective in the control of tumor progression. After the injection of such a drug, a decrease in serotonin and 5-hydroxy-indoleacetic acid serum levels was observed as well as a reduction in the urinary metabolite. It is concluded that octreotide is very useful for the symptomatic treatment of carcinoid syndrome.
- Valencia [Material gráfico] : Festividad de San José : típicas fallas, grandes corridas de toros : 14 al 19 de marzo de 1931 / F. Molina XXXI([S.l. : s.n., 2012-11-30) Monreal, M. (M.); Machí, E
- Sistema Renina-Angiotensina y función antehipofisaria: ¿Interacción endocrina o modulación paracrina?(Universidad de Navarra, 1992) Recio, J.M. (J. M.); Moncada, E. (Emilio); Monreal, M. (M.); Salvador, J. (Javier); Yoldi, A. (A.); Oleaga, A. (A.)La identificación de componentes del sistema renina-angiotensina y receptores celulares para angiotensina II (Ag II) en las células hipotalamo-hipofisarias sugirió una posible modulación de Ag II en la secreción-hipofisaria. Esta influencia ha sido confirmada posteriormente tanto «in vivo» como «in vitro» evidenciándose un efecto potenciador de la secreción de hormona de crecimiento (GH) y ACTH, y variable sobre la secreción de prolactina (PRL). No se han observado modificaciones «in vivo» sobre TSH y gonadotrofinas. La administración de inhibidores del enzima convertidor de la angiotensina disminuye los niveles periféricos de Ag II, produciendo una leve disminución de las concentraciones de GH y PRL. Sin embargo, el mecanismo por el que Ag II es capaz de modular la secreción adenohipofisaria aún permanece oscuro, desconociéndose si es un efecto directo o a través de factores hipotalámicos y, si existe una modulación endocrina o exclusivamente paracrina.
- Effect of the time of diagnosis on outcome in patients with acute venous thromboembolism(Schattauer, 2011) Rosa, V. (Vladimir); RIETE, Investigators; Ciammaichella, M.M. (Maurizio M.); Monreal, M. (M.); Soler, S. (Silvia); Raquel; Lecumberri, R. (Ramón); Toro, J. (Jorge) delThe influence of the day of diagnosis (weekends vs. weekdays) on outcome in patients with acute venous thromboembolism (VTE) has not been thoroughly studied. We used the RIETE database to compare the clinical characteristics, treatment details, and mortality rate at 7 and 30 days, of all patients diagnosed with acute VTE on weekends versus those diagnosed on weekdays. Up to January 2010, 30,394 patients were included in RIETE, of whom 5,479 (18%) were diagnosed on weekends. Most clinical characteristics were similar in both groups, but patients diagnosed on weekends had less often cancer (20% vs. 22%; p=0.004), and presented more likely with pulmonary embolism (PE) than those diagnosed on weekdays (52% vs. 47%; p <0.001). Most patients in both groups received initial therapy with low-molecular-weight heparin (90% and 91%, respectively; p=0.01), then switched to vitamin K antagonists (72% and 71%, respectively; p=0.007). The 7-day mortality rate in patients presenting with PE was 2.75% in those diagnosed on weekends versus 3.00% in those diagnosed on weekdays (p=0.49). At 30 days, the mortality rate was 6.51% versus 6.06%, respectively (p=0.38). In patients presenting with deep vein thrombosis alone, the 7-day mortality rate in those diagnosed on weekends was 1.04% versuss 0.66% in those diagnosed on weekdays (p=0.053). The mortality rate at 30 days was of 3.41% versus 2.88% (p=0.14), respectively. In RIETE, the clinical characteristics, treatment strategies, and 7- and 30-day mortality rates of patients diagnosed on weekends were similar to those in patients diagnosed on weekdays.