Vitelli-Storelli, F. (Facundo)
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- Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain(MDPI, 2020) Jiménez-Moleón, J.J. (José Juan); Molina, A.J. (Antonio José); Fernández-Tardón, G. (Guillermo); Kogevinas, M. (Manolis); Chirlaque, M.D. (María-Dolores); Molina-Barceló, A. (Ana); Toledo, E. (Estefanía); Alguacil, J. (Juan); Aragonés, N. (Nuria); Castaño-Vinyals, G. (Gemma); Rubín-García, M. (María); Adarnaz, E. (Eva); Obón-Santacana, M. (Mireia); Pollán, M. (Marina); Zamora-Ros, R. (Raúl); Vitelli-Storelli, F. (Facundo); Gómez-Acebo, I. (Inés); Martin, V. (Vicente); Gómez, B. (Beatriz)Abstract: Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake.
- Associations between dietary polyphenols and type 2 diabetes in a cross-sectional analysis of the PREDIMED-plus trial: Role of body mass index and sex(MDPI AG, 2019) Babio, N. (Nancy); Hernáez, Á. (Álvaro); Fernandez-Garcia, J.C. (José C.); Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Fito, M. (Montserrat); Tojal-Sierra, L. (Lucas); Álvarez-Pérez, J. (Jacqueline); Konieczna, J. (Jadwiga); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); Vioque, J. (Jesús); Becerra-Tomas, N. (Nerea); Tur, J.A. (Josep A.); Martinez-Lacruz, R. (Raul); Galera-Cusí, A. (Ana); Romaguera, D. (Dora); Tresserra-Rimbau, A. (Anna); Lapetra, J. (José); Pastor-Polo, C. (Concepción); Matía-Martín, P. (Pilar); Rubín-García, M. (María); Delgado-Rodriguez, M. (Miguel); López-Miranda, J. (José); Galdon, A. (Alba); Galmes-Panades, A.M. (Aina M.); Castro-Barquero, S. (Sara); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Notario-Barandiaran, L. (Leyre); Perez-Vega, K.A. (Karla Alejandra); Julibert, A. (Alicia); Vitelli-Storelli, F. (Facundo); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); García-Molina, L. (Laura); Estruch, R. (Ramón); Vazquez-Ruiz, Z. (Zenaida); Diaz-Lopez, A. (Andres); Santos-Lozano, J.M. (José M.); Lamuela-Raventos, R.M. (Rosa Maria); Pérez-Lopez, J. (Jessica); Gea, A. (Alfredo); Serra-Majem, L. (Luis); Corella, D. (Dolores); Basterra-Gortari, F.J. (Francisco Javier); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Sorli, J.V. (Jose V.); Moreno-Rodríguez, A. (Anai)Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals with high body mass index (BMI) may have altered absorption or metabolism of some nutrients and dietary components, including polyphenols. Therefore, we aimed to assess whether high intakes of some classes of polyphenols are associated with T2D in a population with metabolic syndrome and how these associations depend on BMI and sex. This baseline cross-sectional analysis includes 6633 participants from the PREDIMED-Plus trial. Polyphenol intakes were calculated from food frequency questionnaires (FFQ). Cox regression models with constant time at risk and robust variance estimators were used to estimate the prevalence ratios (PRs) for polyphenol intake and T2D prevalence using the lowest quartile as the reference group. Analyses were stratified by sex and BMI groups (overweight and obese) to evaluate potential effect modification. Catechins, proanthocyanidins, hydroxybenzoic acids, and lignans were inversely associated with T2D. Hydroxycinnamic acids were directly related in men. These associations were different depending on sex and BMI, that is, women and overweight obtained stronger inverse associations
- Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort(2023) Martinez-Gonzalez, M.A. (Miguel Ángel); Toledo, E. (Estefanía); Bes-Rastrollo, M. (Maira); Vitelli-Storelli, F. (Facundo); Vazquez-Ruiz, Z. (Zenaida); Basterra-Gortari, F.J. (Francisco Javier)The global incidence of type 2 diabetes (T2D) has been steadily increasing in recent decades. The Mediterranean dietary pattern has shown a preventive effect on the risk of T2D. Evaluating the association between bioactive compounds such as phenolic compounds (PC) in a Mediterranean cohort could help to better understand the mechanisms implicated in this protection. We evaluated the association between dietary intake of PC and the risk of T2D in a relatively young cohort of 17,821 Spanish participants initially free of T2D, through the University of Navarra Follow-up Project (Seguimiento Universidad de Navarra or SUN cohort) after 10 years of median follow-up using time-dependent Cox models. Intake of PC was estimated at baseline and repeatedly at 10-year follow-up using a 136-item validated food frequency and the Phenol-Explorer database. The incidence of T2D was identified by a biennial follow-up, and only medically confirmed cases were included. During 224,751 person-years of follow-up, 186 cases of T2D were confirmed. A suboptimal intake of stilbenes was independently associated with a higher risk of T2D in subjects over 50 years (HR: 1.75, 95% CI: 1.06-2.90, p value < 0.05) after adjusting for potential confounders. Our results suggest that a moderate-high intake of stilbenes can decrease the risk of developing T2D in subjects over 50 years in our cohort.
- Total polyphenol intake and breast cancer risk in the Seguimiento Universidad de Navarra (SUN) cohort(Cambridge University Press, 2018-12-27) Gardeazabal, I. (Itziar); Martinez-Gonzalez, M.A. (Miguel Ángel); Romanos-Nanclares, A. (Andrea); Sanchez-Bayona, R. (Rodrigo); Toledo, E. (Estefanía); Aramendia, J.M. (José Manuel); Vitelli-Storelli, F. (Facundo); Gaforio, J.J. (José Juan)Polyphenols are a wide family of phytochemicals present in diverse foods. They might play a role in cancer development and progression. In vivo and in vitro studies have suggested beneficial properties and potential mechanisms. We aimed to evaluate the association between total and main classes of polyphenol intake and breast cancer (BC) risk in the Seguimiento Universidad de Navarra project – a prospective Mediterranean cohort study. We included 10 713 middle-aged, Spanish female university graduates. Polyphenol intake was derived from a semi-quantitative FFQ and matching food consumption data from the Phenol-Explorer database. Women with self-reported BC were asked to return a copy of their medical report for confirmation purposes; death certificates were used for fatal cases. Cox models were fitted to estimate multivariable-adjusted hazard ratios (HR) and 95 % CI for the association between tertiles (T) of polyphenol intake and BC. After 10·3 years of median follow-up, 168 probable incident BC cases were identified, out of which 100 were confirmed. We found no association between polyphenol intake and the overall BC risk. Nevertheless, we observed a significant inverse association between total polyphenol intake and BC risk for postmenopausal women, either for probable or only for confirmed cases (HRT3 v. T1 0·31 (95 % CI 0·13, 0·77; Ptrend=0·010)). Also, phenolic acid intake was inversely associated with postmenopausal BC. In summary, we observed no significant association between total polyphenol intake and BC risk. Despite a low number of incident BC cases in our cohort, higher total polyphenol intake was associated with a lower risk of postmenopausal BC.
- Dietary polyphenol Intake is associated with HDL-Cholesterol and a better profile of other components of the metabolic syndrome: a PREDIMED-Plus sub-study(MDPI, 2020) Buil, P. (Pilar); Martinez, J.A. (José Alfredo); Garcia-Rios, A. (Antonio); Fito, M. (Montserrat); Martín-Sánchez, V. (Vicente); Tinahones, F.J. (Francisco J.); Vioque, J. (Jesús); Martin-Calvo, N. (Nerea); Tur, J.A. (Josep A.); Romaguera, D. (Dora); Tresserra-Rimbau, A. (Anna); Lapetra, J. (José); Rubín-García, M. (María); Castro-Barquero, S. (Sara); Vitelli-Storelli, F. (Facundo); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); Doménech, M. (Mónica); Serra-Majem, L. (Luis); Corella, D. (Dolores); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi)Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.