Kozor, R. (Rebecca)

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    Reverse myocardial remodeling following valve replacement in patients with aortic stenosis
    (Elsevier BV, 2018) Manisty, C. (Charlotte); Schofield, R.S. (Rebecca S.); Bhuva, A.N. (Anish N.); Treibel, T.A. (Thomas A.); Sheikh, A. (Amir); Benedetti, G. (Giulia); Moon, J.C. (James C.); Gonzalez, A. (Arantxa); Lloyd, G. (Guy); Kellman, P. (Peter); Kozor, R. (Rebecca); López, B. (Begoña); Diez, J. (Javier); Fontana, M. (Marianna)
    Background Left ventricular (LV) hypertrophy, a key process in human cardiac disease, results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis). Objectives This study sought to investigate whether human myocardial interstitial fibrosis in aortic stenosis (AS) is plastic and can regress.
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    Sex dimorphism in the myocardial response to aortic stenosis
    (Elsevier, 2018) Torlasco, C. (Camilla); Espinoza, M. (Maria); Badiani, S. (Sveeta); Hughes, A.D. (Alun D.); Reant, P. (Patricia); Treibel, T.A. (Thomas A.); Moon, J.C. (James C.); Lloyd, G. (Guy); Kozor, R. (Rebecca); Yap, J. (John); Diez, J. (Javier); Fontana, M. (Marianna)
    Objectives: The goal of this study was to explore sex differences in myocardial remodeling in aortic stenosis (AS) by using echocardiography, cardiac magnetic resonance (CMR), and biomarkers. Background: AS is a disease of both valve and left ventricle (LV). Sex differences in LV remodeling are reported in AS and may play a role in disease phenotyping. Methods: This study was a prospective assessment of patients awaiting surgical valve replacement for severe AS using echocardiography, the 6-min walking test, biomarkers (high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide), and CMR with late gadolinium enhancement and extracellular volume fraction, which dichotomizes the myocardium into matrix and cell volumes. LV remodeling was categorized into normal geometry, concentric remodeling, concentric hypertrophy, and eccentric hypertrophy.