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Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
(MDPI, 2020) Jiménez-Moleón, J.J. (José Juan); Molina, A.J. (Antonio José); Fernández-Tardón, G. (Guillermo); Kogevinas, M. (Manolis); Chirlaque, M.D. (María-Dolores); Molina-Barceló, A. (Ana); Toledo, E. (Estefanía); Alguacil, J. (Juan); Aragonés, N. (Nuria); Castaño-Vinyals, G. (Gemma); Rubín-García, M. (María); Adarnaz, E. (Eva); Obón-Santacana, M. (Mireia); Pollán, M. (Marina); Zamora-Ros, R. (Raúl); Vitelli-Storelli, F. (Facundo); Gómez-Acebo, I. (Inés); Martin, V. (Vicente); Gómez, B. (Beatriz)
Abstract: Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake.