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Identification of tissue microRNAs predictive of sunitinib activity in patients with metastatic renal cell carcinoma
(Public Library of Science, 2014) Carles, J. (Joan); Gallardo, E. (Enrique); Arranz, J.A. (Jose Ángel); Lozano, M.D. (María Dolores); Prior, C. (Celia); Perez-Gracia, J.L. (Jose Luis); Climent, M.A. (Miguel Ángel); Bellmunt, J. (Joaquim); Rodriguez-Antona, C. (Cristina); Lopez-Picazo, J.M. (José M.); Esteban-Gutiérrez, E. (Emilio); Gonzalez-Hernandez, A. (Alvaro); Gurpide, A. (Alfonso); Garcia-Donas, J. (Jesús); Moreno, F. (Fernando); Gonzalez-del-Alba, A. (Aránzazu); Font, A. (Albert); Suárez, C. (Cristina); Guruceaga, E. (Elizabeth); Mellado, B. (Begoña); Martinez, E. (Esther); Castellano, D. (Daniel); Calvo-González, A. (Alfonso); Puente, J. (Javier)
We identified differentially expressed microRNAs in MRCC patients presenting marked sensitivity or resistance to sunitinib. MiR-942 was the best predictor of efficacy. We describe a novel paracrine mechanism through which high miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance. Our results support further validation of these miRNA in clinical confirmatory studies.