Corbella, E. (Emili)
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- Relationship of visceral adipose tissue with surrogate insulin resistance and liver markers in individuals with metabolic syndrome chronic complications(Sage journals, 2020) Martinez, J.A. (José Alfredo); Corbella, E. (Emili); Martinez-Gonzalez, M.A. (Miguel Ángel); Fito, M. (Montserrat); Konieczna, J. (Jadwiga); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); Zulet, M.A. (María Ángeles); Tur, J.A. (Josep A.); Toledo, E. (Estefanía); Romaguera, D. (Dora); Macías-González, M. (Manuel); Ros, E. (Emilio); Estruch, R. (Ramón); Corella, D. (Dolores); Abete, I. (Itziar); Mascaró, C.M. (Catalina M.); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Sayon-Orea, C. (Carmen); Bullón-Vela, M. V. (María Vanessa)Background: Visceral adipose tissue (VAT) has a hazardous influence on systemic inflammation, insulin resistance and an adverse metabolic profile, which increases the risk of developing non-alcoholic fatty liver disease (NAFLD) and chronic complications of diabetes. In our study we aimed to evaluate the association of VAT and the triglyceride glucose (TyG) as a proxy of insulin resistance surrogated with metabolic and liver risk factors among subjects diagnosed with metabolic syndrome (MetS). Methods: A cross-sectional study was performed including 326 participants with MetS (55– 75years) from the PREDIMED-Plus study. Liver-status markers, VAT and TyG were assessed. Participants were stratified by tertiles according to VAT (n=254) and TyG (n=326). A receiver operating characteristic curve was used to analyse the efficiency of TyG for VAT. Results: Subjects with greater visceral fat depots showed worse lipid profile, higher homeostatic model assessment for insulin resistance (HOMA-IR), TyG, alanine transaminase (ALT), fibroblast growth factor-21 (FGF-21), fatty liver index (FLI) and hepatic steatosis index (HSI) compared with participants in the first tertile. The multi-adjusted linear-regression analyses indicated that individuals in the third tertile of TyG (>9.1−10.7) had a positive association with HOMA-IR [β=3.07 (95% confidence interval (CI) 2.28−3.86; p trend<0.001)], ALT [β=7.43 (95% CI 2.23−12.63; p trend=0.005)], gamma glutamyl transferase (GGT) [β=14.12 (95% CI 3.64−24.61; p trend=0.008)], FGF-21 [β=190.69 (95% CI 93.13−288.25; p trend<0.001)], FLI [β=18.65 (95% CI 14.97−22.23; p trend<0.001)] and HSI [β=3.46 (95% CI, 2.23−4.68; p trend<0.001)] versus participants from the first tertile. Interestingly, the TyG showed the largest area under the receiver operating curve (AUC) for women (AUC=0.713; 95% CI 0.62−0.79) compared with men (AUC=0.570; 95% CI 0.48−0.66). Conclusions: A disrupted VAT enlargement and impairment of TyG are strongly associated with liver status and cardiometabolic risk factors linked with NAFLD in individuals diagnosed with MetS. Moreover, the TyG could be used as a suitable and reliable marker estimator of VAT.
- Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk(MDPI AG, 2019) Babio, N. (Nancy); Fernandez-Garcia, J.C. (José C.); Castañer, O. (Olga); Oncina-Canovas, A. (Alejandro); Corbella, E. (Emili); Martinez-Gonzalez, M.A. (Miguel Ángel); Muñoz-Garach, A. (Araceli); Salaverria-Lete, I. (Itziar); Garcia-Rios, A. (Antonio); Tojal-Sierra, L. (Lucas); Martín-Sánchez, V. (Vicente); Pérez-Farinós, N. (Napoleón); Daimiel, L. (Lidia); Quifer, M. (Mireia); Compañ-Gabucio, L. (Laura); Vioque, J. (Jesús); Barón-López, F.J. (F. Javier); Becerra-Tomas, N. (Nerea); Tur, J.A. (Josep A.); Colom, A. (Antoni); Diez-Espino, J. (Javier); Romaguera, D. (Dora); Vázquez, C. (Clotilde); Lapetra, J. (José); Matía-Martín, P. (Pilar); Bueno-Cavanillas, A. (Aurora); Papandreou, C. (Christopher); Schröder, H. (Helmut); Delgado-Rodriguez, M. (Miguel); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Bullo, M. (Monica); Bibiloni, M.M. (Maria del Mar); Casas, R. (Rosa); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); Estruch, R. (Ramón); Diaz-Lopez, A. (Andres); Cenoz-Osinaga, J.C. (Juan C.); Asensio, E.M. (Eva M.); Martinez, A. (Alfredo); Santos-Lozano, J.M. (José M.); Torras, L. (Laura); Sanchez-Villegas, A. (Almudena); Serra-Majem, L. (Luis); Corella, D. (Dolores); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Sorli, J.V. (Jose V.); Morey, M. (Marga)The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndromein the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = 0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = 0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.
- Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial(Wiley, 2019) Babio, N. (Nancy); Buil, P. (Pilar); Martinez, J.A. (José Alfredo); Corbella, E. (Emili); Fiol, M. (Miquel); Rosique-Esteban, N. (Nuria); Bartolomé, R. (Rafael); Konieczna, J. (Jadwiga); Daimiel, L. (Lidia); Zulet, M.A. (María Ángeles); Toledo, E. (Estefanía); Romaguera, D. (Dora); Paz, J.A. (José Antonio) de; Vera, J. (Josep); Galmes-Panades, A.M. (Aina M.); Razquin, C. (Cristina); Ibero-Baraibar, I. (Idoia); Portillo, M.P. (María P.); Casas, R. (Rosa); Goday, A. (Albert); Estruch, R. (Ramón); Diaz-Lopez, A. (Andres); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Martin, V. (Vicente); PREDIMED-PLUS InvestigatorsBackground Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0.05), visceral fat and leucocyte count (all P-trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-to-lymphocyte ratio, and platelet count (all P-trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance. Conclusions Diet and PA are important regulatory mediators of systemic inflammation, which is directly involved in the sarcopenic process. A healthy dietary pattern combined with exercise is a promising strategy to limit age-related sarcopenia.