Morales-de-Alava, I. (Isabel)

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2003 - 200912010 - 20181

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    Significant dose reduction is feasible in FDG PET/CT protocols without compromising diagnostic quality
    (Elsevier, 2018) Marti-Climent, J.M. (Josep María); Peñuelas-Sanchez, I. (Ivan); Sancho, L. (Lidia); Morales-de-Alava, I. (Isabel); Guillen, F. (Fernando); Prieto-Azcárate, E. (Elena); Richter, J.A. (José Ángel); Garcia-Velloso, M. J. (María José); Moran, V. (Verónica); García-García, B. (Berta); Rodriguez-Fraile, M. (Macarena)
    Purpose: To reduce the radiation dose to patients by optimizing oncological FDG PET/CT protocols. Methods: The baseline PET/CT protocol in our institution for oncological PET/CT examinations consisted of the administration of 5.18 MBq/kg of FDG and a CT acquisition with a reference current-time product of 120 mAs. In 2016, FDG activity was reduced to 4.44 and 3.70 MBq/kg and reference CT current-time-product was reduced to 100 and 80 mAs. 322 patients scanned with different protocols were retrospectively evaluated. For each patient, effective dose was calculated. The overall image quality was subjectively rated by the referring physician on a 4-point scale (IQ score: 1 excellent, 2 good, 3 poor but interpretable, 4 poor not interpretable). Image quality was quantitatively evaluated measuring noise in the liver. Results: CT Results: Effective dose was progressively reduced from 9.5 ± 2.8 to 8.0 ± 2.3 and 6.2 ± 1.5 mSv (p < 0.001). A mean dose reduction of 34.9% was achieved. There was a significant degradation of IQ score (p < 0.05) and noise (p < 0.001). Nevertheless, the number of poor quality studies (IQ score >2) did not increase. PET Results: Effective dose was gradually reduced from 6.5 ± 1.4 to 5.7 ± 1.3 and 5.0 ± 1.0 mSv (p < 0.001). Average dose reduction was 23.4%. IQ score (p < 0.05) and noise (p < 0.001) significantly degraded for lower activity protocols. However, all images with reduced activity were scored as interpretable (IQ score ≤ 3). Conclusions: A significant radiation dose reduction of 28.7% was reached. Despite a slight reduction in image quality, the new regime was successfully implemented with readers reporting unchanged clinical confidence.
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    Información de medicamentos a la población desde el Servicio de Farmacia a través de Internet
    (Elsevier España, 2003) Lacasa, C. (Carlos); Aldaz, A. (Azucena); Morales-de-Alava, I. (Isabel); Ortega-Eslava, A. (Ana); Idoate, A. (Antonio); Conchillo, A. (Ana); Giraldez, J. (J.); Aquerreta, I. (Irene); Yuste, J.R. (José Ramón); Garcia, N. (Nicolás); Beorlegui, B. (Blanca)
    Objectives: To describe and discuss the work of a Pharmacy Department for the health-care portal www.viatusalud.com. Methods: Using a web portal, a Pharmacy Department develops and updates a vademecum on drugs, and answers enquiries by end-users. Results: On December 31, 2002 more than 750 records on drugs were available, and 3030 enquiries had been answered. Conclusions: With this drug information and online enquiry service, our Pharmacy Department helps meet the demand of health-care information posed by the community and by patients previously seen at Clínica Universitaria. In addition, it allows areas of improvement to be detected in the information to be offered to patients fron a Pharmacy Department, and represents a tertiary source of information for health-care professionals.