Goday, A. (Albert)

Filtering

2018 - 201942020 - 20223

Settings

Author search.filters.isAuthorOfPublication.81b2667a-289a-44b9-b057-66c15f307542

Search Results

Now showing 1 - 7 of 7
  • Thumbnail Image
    Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial
    (Wiley, 2019) Babio, N. (Nancy); Buil, P. (Pilar); Martinez, J.A. (José Alfredo); Corbella, E. (Emili); Fiol, M. (Miquel); Rosique-Esteban, N. (Nuria); Bartolomé, R. (Rafael); Konieczna, J. (Jadwiga); Daimiel, L. (Lidia); Zulet, M.A. (María Ángeles); Toledo, E. (Estefanía); Romaguera, D. (Dora); Paz, J.A. (José Antonio) de; Vera, J. (Josep); Galmes-Panades, A.M. (Aina M.); Razquin, C. (Cristina); Ibero-Baraibar, I. (Idoia); Portillo, M.P. (María P.); Casas, R. (Rosa); Goday, A. (Albert); Estruch, R. (Ramón); Diaz-Lopez, A. (Andres); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Martin, V. (Vicente); PREDIMED-PLUS Investigators
    Background Sarcopenia is a progressive age-related skeletal muscle disorder associated with increased likelihood of adverse outcomes. Muscle wasting is often accompanied by an increase in body fat, leading to ‘sarcopenic obesity’. The aim of the present study was to analyse the association of lifestyle variables such as diet, dietary components, physical activity (PA), body composition, and inflammatory markers, with the risk of sarcopenic obesity. Methods A cross-sectional analysis based on baseline data from the PREDIMED-Plus study was performed. A total of 1535 participants (48% women) with overweight/obesity (body mass index: 32.5 ± 3.3 kg/m2; age: 65.2 ± 4.9 years old) and metabolic syndrome were categorized according to sex-specific tertiles (T) of the sarcopenic index (SI) as assessed by dual-energy X-ray absorptiometry scanning. Anthropometrical measurements, biochemical markers, dietary intake, and PA information were collected. Linear regression analyses were carried out to evaluate the association between variables. Results Subjects in the first SI tertile were older, less physically active, showed higher frequency of abdominal obesity and diabetes, and consumed higher saturated fat and less vitamin C than subjects from the other two tertiles (all P < 0.05). Multiple adjusted linear regression models evidenced significant positive associations across tertiles of SI with adherence to the Mediterranean dietary score (P-trend < 0.05), PA (P-trend < 0.0001), and the 30 s chair stand test (P-trend < 0.0001), whereas significant negative associations were found with an inadequate vitamin C consumption (P-trend < 0.05), visceral fat and leucocyte count (all P-trend < 0.0001), and some white cell subtypes (neutrophils and monocytes), neutrophil-to-lymphocyte ratio, and platelet count (all P-trend < 0.05). When models were additionally adjusted by potential mediators (inflammatory markers, diabetes, and waist circumference), no relevant changes were observed, only dietary variables lost significance. Conclusions Diet and PA are important regulatory mediators of systemic inflammation, which is directly involved in the sarcopenic process. A healthy dietary pattern combined with exercise is a promising strategy to limit age-related sarcopenia.
  • Thumbnail Image
    Lifestyle factors and visceral adipose tissue: Results from the PREDIMED-PLUS study
    (Public Library of Science (PLoS), 2019) Babio, N. (Nancy); Buil, P. (Pilar); Fiol, M. (Miquel); Rosique-Esteban, N. (Nuria); Konieczna, J. (Jadwiga); Zulet, M.A. (María Ángeles); Colom, A. (Antoni); Toledo, E. (Estefanía); Romaguera, D. (Dora); Paz, J.A. (José Antonio) de; Vera, J. (Josep); Galmes-Panades, A.M. (Aina M.); Casas, R. (Rosa); Goday, A. (Albert); Estruch, R. (Ramón); Vazquez-Ruiz, Z. (Zenaida); Martinez, A. (Alfredo); Abete, I. (Itziar); Vidal, J. (Josep); Salas-Salvado, J. (Jordi); PREDIMED-PLUS Investigators
    Background: Visceral adipose tissue (VAT) is a strong predictor of cardiometabolic health, and lifestyle factors may have a positive influence on VAT depot. This study aimed to assess the cross-sectional associations between baseline levels of physical activity (PA), sedentary behaviours (SB) and adherence to the Mediterranean diet (MedDiet) with VAT depot in older individuals with overweight/obesity and metabolic syndrome. Methods: Baseline data of the PREDIMED-Plus study including a sample of 1,231 Caucasian men and women aged 55-75 years were used. Levels of leisure-time PA (total, light, and moderate-to-vigorous, in METs·min/day) and SB (total and TV-viewing, in h/day) were evaluated using validated questionnaires. Adherence to the MedDiet was evaluated using a 17-item energy-restricted MedDiet (erMedDiet) screener. The chair-stand test was used to estimate the muscle strength. VAT depot was assessed with DXA-CoreScan. Multivariable adjusted linear regression models were used to evaluate the association between lifestyle factors and VAT. For the statistics we had used multiadjusted linear regression models. Results: Total leisure-time PA (100 METs·min/day: β -24.3g, -36.7;-11.9g), moderate-to-vigorous PA (β -27.8g, 95% CI -40.8;-14.8g), chair-stand test (repeat: β -11.5g, 95% CI -20.1;-2.93g) were inversely associated, and total SB (h/day: β 38.2g, 95% CI 14.7;61.7) positively associated with VAT. Light PA, TV-viewing time and adherence to an erMedDiet were not significantly associated with VAT. Conclusions: In older adults with overweigh/obesity and metabolic syndrome, greater PA, muscle strength, and lower total SB were associated with less VAT depot. In this study, adherence to an erMedDiet was not associated with lower VAT.
  • Thumbnail Image
    Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study
    (MDPI, 2020) Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Oncina-Canovas, A. (Alejandro); Garcia-Rios, A. (Antonio); Tojal-Sierra, L. (Lucas); Gimenez-Alba, I.M. (Ignacio Manuel); Martín-Sánchez, V. (Vicente); Martín, M. (Marian); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); García-Gavilán, J.F. (Jesús F.); Vioque, J. (Jesús); Becerra-Tomas, N. (Nerea); Tur, J.A. (Josep A.); Romaguera, D. (Dora); Vázquez, C. (Clotilde); Lapetra, J. (José); Zomeño, M.D. (María Dolores); Matía-Martín, P. (Pilar); Bouzas, C. (Cristina); Angullo-Martínez, E. (Escarlata); Bueno-Cavanillas, A. (Aurora); Casañas-Quintana, T. (Tamara); Basora, J. (Josep); Belló-Mora, M.C. (María C.); Castro-Barquero, S. (Sara); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Notario-Barandiaran, L. (Leyre); Fernández-Lázaro, C.I. (César I.); Bibiloni, M.M. (Maria del Mar); Julibert, A. (Alicia); Goday, A. (Albert); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); Estruch, R. (Ramón); Saiz, C. (Carmen); Gaforio, J.J. (José Juan); Santos-Lozano, J.M. (José M.); Pérez-Lopez, J. (Jessica); Serra-Majem, L. (Luis); Corella, D. (Dolores); Basterra-Gortari, F.J. (Francisco Javier); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Muñoz, J. (Julia); Salas-Salvado, J. (Jordi); Morey, M. (Marga); Bernal-López, M.R. (María Rosa); Galera, A. (Ana); Sayon-Orea, C. (Carmen)
    Background. Body weight dissatisfaction is a hindrance to following a healthy lifestyle and it has been associated with weight concerns. Objectives. The aim of this study was to assess the association between the adherence to the Mediterranean lifestyle (diet and exercise) and the desired body weight loss in an adult Mediterranean population with overweight. Methods. Cross-sectional analysis in 6355 participants (3268 men; 3087 women) with metabolic syndrome and BMI (Body mass index) between 27.0 and 40.0 kg/m2 (55–75 years old) from the PREDIMED-Plus trial. Desired weight loss was the percentage of weight that participants wished to lose. It was categorized into four cut-offs of this percentage (Q1: <10%, n = 1495; Q2: 10–15%, n = 1804; Q3: <15–20%, n = 1470; Q4: ≥20%, n = 1589).
  • Thumbnail Image
    Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial
    (2022) Castañer, O. (Olga); Martinez-Gonzalez, M.A. (Miguel Ángel); Fito, M. (Montserrat); Tinahones, F.J. (Francisco J.); Toloba, A. (A.); Hernando-Redondo, J. (J.); Benaiges, D. (D.); Ros, E. (Emilio); Goday, A. (Albert); Estruch, R. (Ramón); Corella, D. (Dolores); Salas-Salvado, J. (Jordi)
    BackgroundObesity is produced by the enlargement of the adipose tissue. Functioning as an endocrine organ, it releases and receives information through a complex network of cytokines, hormones, and substrates contributing to a low-chronic inflammation environment. Diet and healthy habits play key roles in the prevention of obesity and its related pathologies. In this regard, there is a need to switch to healthier and more appetizing diets, such as the Mediterranean one. ObjectiveTo compare the mid-and long-term effects of two Mediterranean diet (MedDiet) interventions, one energy-reduced plus physical activity promotion versus a non-restrictive diet, on peripheral satiety-related hormones, weight loss, glucose/lipid metabolism, and pro-inflammatory markers in subjects with obesity/overweight and metabolic syndrome. Materials and methodsA randomized, lifestyle intervention was conducted in 23 Spanish centers, with a large cohort of patients presenting metabolic syndrome. Our study is a subproject set in IMIM (Hospital del Mar Research Institute). Participants were men and women, aged 55-75 and 60-75, respectively, who at baseline met at least three metabolic syndrome components. Subjects were assigned to two intervention groups: (1) an intensive lifestyle intervention with an energy-reduced MedDiet and physical activity promotion (intervention group) with the aim of weight loss; and (2) a normocaloric MedDiet (control). We quantified in a subsample of 300 volunteers from Hospital del Mar Research Institute (Barcelona), following analytes at baseline, 6 months, and 1 year: glucose, HbA1c, triglycerides, total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, C-peptide, ghrelin, GLP-1, glucagon, insulin, leptin, PAI-1, resistin, and visfatin. Anthropometric and classical cardiovascular risk factors were also determined. A multivariate statistical model was employed to compare the two groups. Linear mixed-effect models were performed to compare changes in risk factors and biomarkers between intervention groups and over time. ResultsCompared to participants in the control group, those in intervention one showed greater improvements in weight, waist circumference, insulin (P < 0.001), glucose metabolism-related compounds (P < 0.05), triglyceride-related lipid profile (P < 0.05), leptin, blood pressure, and pro-inflammatory markers such as PAI-1 (P < 0.001) at mid-and/or long-term. High-sensitivity C-reactive protein, resistin, and vifastin also decreased in both groups. ConclusionA weight loss intervention employing a hypocaloric MedDiet and physical activity promotion has beneficial effects on adiposity, glucose metabolism, lipid profile, leptin, and pro-inflammatory markers, such as PAI-1 in both mid-and long-term.
  • Thumbnail Image
    Long daytime napping is associated with increased adiposity and type 2 diabetes in an elderly population with metabolic syndrome
    (MDPI AG, 2019) Babio, N. (Nancy); Buil, P. (Pilar); Fernandez-Garcia, J.C. (José C.); Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Martinez-Gonzalez, M.A. (Miguel Ángel); Trias, F. (Ferran); Muñoz-Garach, A. (Araceli); Garcia-Rios, A. (Antonio); Gallardo-Alfaro, L. (Laura); Fito, M. (Montserrat); Martín-Sánchez, V. (Vicente); Pérez-Farinós, N. (Napoleón); Konieczna, J. (Jadwiga); González-Botella, A. (Andrés); Daimiel, L. (Lidia); Vaquero-Luna, J. (Jessica); Vioque, J. (Jesús); Barón-López, F.J. (F. Javier); Becerra-Tomas, N. (Nerea); García Hera, M (Manoli) de la; Tur, J.A. (Josep A.); Martinez-Lacruz, R. (Raul); Toledo, E. (Estefanía); Romaguera, D. (Dora); Vázquez, C. (Clotilde); Lapetra, J. (José); Matía-Martín, P. (Pilar); Bueno-Cavanillas, A. (Aurora); Papandreou, C. (Christopher); Schröder, H. (Helmut); Delgado-Rodriguez, M. (Miguel); Galmes-Panades, A.M. (Aina M.); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Bullo, M. (Monica); Casas, R. (Rosa); Goday, A. (Albert); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); Estruch, R. (Ramón); Diaz-Lopez, A. (Andres); Santos-Lozano, J.M. (José M.); Serra-Majem, L. (Luis); Corella, D. (Dolores); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Barragán-Arnal, R. (Rocío); Bautista-Castaño, I. (Inmaculada); Moreno-Rodríguez, A. (Anai)
    Research examining associations between objectively-measured napping time and type 2 diabetes (T2D) is lacking. This study aimed to evaluate daytime napping in relation to T2D and adiposity measures in elderly individuals from the Mediterranean region. A cross-sectional analysis of baseline data from 2190 elderly participants with overweight/obesity and metabolic syndrome, in the PREDIMED-Plus trial, was carried out. Accelerometer-derived napping was measured. Prevalence ratios (PR) and 95% confidence intervals (CI) for T2D were obtained using multivariable-adjusted Cox regression with constant time. Linear regression models were fitted to examine associations of napping with body mass index (BMI) and waist circumference (WC). Participants napping ≥90 min had a higher prevalence of T2D (PR 1.37 (1.06, 1.78)) compared with those napping 5 to <30 min per day. Significant positive associations with BMI and WC were found in those participants napping ≥30 min as compared to those napping 5 to <30 min per day. The findings of this study suggest that longer daytime napping is associated with higher T2D prevalence and greater adiposity measures in an elderly Spanish population at high cardiovascular risk.
  • Thumbnail Image
    Factors associated with successful dietary changes in an energy-reduced Mediterranean diet intervention: a longitudinal analysis in the PREDIMED-plus trial
    (Springer, 2022) Buil, P. (Pilar); Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Oncina-Canovas, A. (Alejandro); Martinez-Gonzalez, M.A. (Miguel Ángel); Garcia-Rios, A. (Antonio); Fito, M. (Montserrat); Tojal-Sierra, L. (Lucas); Martín-Sánchez, V. (Vicente); Pérez-Farinós, N. (Napoleón); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); García-Gavilán, J.F. (Jesús F.); Vioque, J. (Jesús); Moñino, M. (Manuel); Ortega-Azorin, C. (Carolina); Zulet, M.A. (María Ángeles); Becerra-Tomas, N. (Nerea); Tur, J.A. (Josep A.); Toledo, E. (Estefanía); Romaguera, D. (Dora); Muralidharan, J. (Jananee); San-Julián-Aranguren, B. (Beatriz); Vázquez, C. (Clotilde); Sacanella, E. (Emilio); Lapetra, J. (José); Matía-Martín, P. (Pilar); Bueno-Cavanillas, A. (Aurora); Schröder, H. (Helmut); Delgado-Rodriguez, M. (Miguel); López-Miranda, J. (José); Goicolea-Güemez, L. (Leire); Razquin, C. (Cristina); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Fernández-Lázaro, C.I. (César I.); Goday, A. (Albert); Alonso-Gomez, A. (Ángel); Wärnberg, J. (Julia); Estruch, R. (Ramón); Vazquez-Ruiz, Z. (Zenaida); Santos-Lozano, J.M. (José M.); Serra-Majem, L. (Luis); Corella, D. (Dolores); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Sorli, J.V. (Jose V.); Bernal-López, M.R. (María Rosa)
    Purpose Long-term nutrition trials may fail to respond to their original hypotheses if participants do not comply with the intended dietary intervention. We aimed to identify baseline factors associated with successful dietary changes towards an energy-reduced Mediterranean diet (MedDiet) in the PREDIMED-Plus randomized trial. Methods Longitudinal analysis of 2985 participants (Spanish overweight/obese older adults with metabolic syndrome) randomized to the active intervention arm of the PREDIMED-Plus trial. Dietary changes were assessed with a 17-item energyreduced MedDiet questionnaire after 6 and 12 months of follow-up. Successful compliance was defned as dietary changes from baseline of≥5 points for participants with baseline scores<13 points or any increase if baseline score was≥13 points. We conducted crude and adjusted multivariable logistic regression models to identify baseline factors related to compliance. Results Consistent factors independently associated with successful dietary change at both 6 and 12 months were high baseline perceived self-efcacy in modifying diet (OR6-month: 1.51, 95% CI 1.25–1.83; OR12-month: 1.66, 95% CI 1.37–2.01), higher baseline fber intake (OR6-month: 1.62, 95% CI 1.07–2.46; OR12-month: 1.62, 95% CI 1.07–2.45), having>3 chronic conditions (OR6-month: 0.65, 95% CI 0.53–0.79; OR12-month: 0.76, 95% CI 0.62–0.93), and sufering depression (OR6-month: 0.80, 95% CI 0.64–0.99; OR12-month: 0.71, 95% CI 0.57–0.88). Conclusion Our results suggested that recruitment of individuals with high perceived self-efcacy to dietary change, and those who initially follow diets relatively richer in fber may lead to greater changes in nutritional recommendations. Participants with multiple chronic conditions, specifcally depression, should receive specifc tailored interventions.
  • Thumbnail Image
    Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial
    (BMC, 2018) Buil, P. (Pilar); Castañer, O. (Olga); Martinez, J.A. (José Alfredo); Martinez-Gonzalez, M.A. (Miguel Ángel); Garcia-Rios, A. (Antonio); Fito, M. (Montserrat); Cárdenas-Fuentes, G. (Gabriela); Daimiel, L. (Lidia); Tinahones, F.J. (Francisco J.); Vioque, J. (Jesús); Tur, J.A. (Josep A.); Lassale, C. (Camille); Toledo, E. (Estefanía); Romaguera, D. (Dora); Vázquez, C. (Clotilde); Lapetra, J. (José); Matía-Martín, P. (Pilar); Bueno-Cavanillas, A. (Aurora); Schröder, H. (Helmut); Basora, J. (Josep); López-Miranda, J. (José); Marcos, A. (Ascensión); Ros, E. (Emilio); Ruiz-Canela, M. (Miguel); Bullo, M. (Monica); Goday, A. (Albert); Wärnberg, J. (Julia); Estruch, R. (Ramón); Asensio, E.M. (Eva M.); Gaforio, J.J. (José Juan); Serra-Majem, L. (Luis); Corella, D. (Dolores); Abete, I. (Itziar); Vidal, J. (Josep); Pinto, X. (Xavier); Salas-Salvado, J. (Jordi); Martin, V. (Vicente); Torres-Collado, L. (Laura); Aros, F. (Fernando)
    Background: The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component. Methods: PREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n = 6059; mean age 65 ± 4.9 years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups. Results: After 12 months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109. 7–136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p < 0.01) in both groups. A significant (p < 0.001) time*intervention group interaction was found for Total-PA and MVPA, meaning the PA trajectory over time differed between the intervention and control groups. Age, sex, education level, and BMI did not moderate the effectiveness of the PA intervention. BMI and WC decreased significantly with increasing MVPA, compared with participants who reported no changes in MVPA.Conclusion: After one year of follow-up, the PREDIMED-Plus PA intervention has been effective in increasing daily PA in older adults