Yañez, L. (Loreto)
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- Stereotactic radiosurgery for the treatment of recurrent high-grade gliomas: long-term follow-up(Cureus, Inc., 2019) Yañez, L. (Loreto); Sallabanda, M. (Morena); Santos, M. (Marcos); Marsiglia, H. (Hugo); Calvo, F.A. (Felipe A.); Sallabanda, K. (Kita)High-grade gliomas (HGG) are the most frequent primary central nervous system tumors; treatment of HCGs includes surgery and post-operative conformal radiotherapy associated with temozolomide (TMZ or procarbazine/lomustine/vincristine [PCV], specifically in patients with anaplastic oligodendrogliomas or anaplastic oligoastrocytomas). However, recurrence is common. Re-irradiation has been utilized in this setting for years and remains a feasible option, although there is always a concern regarding toxicity. Modern high-precision conformal techniques, including stereotactic radiosurgery (SRS), could improve the therapeutic ratio by delivering high biologically equivalent doses while reducing high-dose radiotherapy (RT) to normal brain tissue. In this paper, we present the results obtained after prolonged follow-up in patients who underwent SRS as a treatment for recurrent high-grade gliomas at San Francisco Hospital in Madrid, Spain.