Stolarz-Skrzypek, K. (Katarzyna)

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    Prevalence of left ventricular diastolic dysfunction in European populations based on cross-validated diagnostic thresholds
    (BioMed Central, 2012) Kawecka-Jaszcz, K. (Kalina); Staessen, J.A. (Jan A.); Casiglia, E. (Edoardo); Kuznetsova, T. (Tatiana); Lopez-Salazar, M.B. (María Begoña); Malyutina, S. (Sofía); Diez-Martinez, J. (Javier); Stolarz-Skrzypek, K. (Katarzyna); Narkiewicz, K. (Krzysztof); Gonzalez, A. (Arantxa); Ryabikov, A. (Andrew); Tikhonoff, V. (Valerie); Kloch-Badelek, M. (Malgorzata); Thijs, L. (Lutgarde); Jin, Y. (Yu); Sakiewicz, W. (Wojciech)
    BACKGROUND: Different diagnostic criteria limit comparisons between populations in the prevalence of diastolic left ventricular (LV) dysfunction. We aimed to compare across populations age-specific echocardiographic criteria for diastolic LV dysfunction as well as their correlates and prevalence. METHODS: We measured the E and A peaks of transmitral blood flow by pulsed wave Doppler and the e' and a' peaks of mitral annular velocities by tissue Doppler imaging (TDI) in 2 cohorts randomly recruited in Belgium (n = 782; 51.4% women; mean age, 51.1 years) and in Italy, Poland and Russia (n = 476; 55.7%; 44.5 years). RESULTS: In stepwise regression, the multivariable-adjusted correlates of the transmitral and TDI diastolic indexes were similar in the 2 cohorts and included sex, age, body mass index, blood pressure and heart rate. Similarly, cut-off limits for the E/A ratio (2.5th percentile) and E/e' ratio (97.5th percentile) in 338 and 185 reference subjects free from cardiovascular risk factors respectively selected from both cohorts were consistent within 0.02 and 0.26 units (median across 5 age groups). The rounded 2.5th percentile of the E/A ratio decreased by ~0.10 per age decade in these apparently healthy subjects. The reference subsample provided age-specific cut-off limits for normal E/A and E/e' ratios. In the 2 cohorts combined, diastolic dysfunction groups 1 (impaired relaxation), 2 (possible elevated LV filling pressure) and 3 (elevated E/e' and abnormally low E/A) encompassed 114 (9.1%), 135 (10.7%), and 40 (3.2%) subjects, respectively. CONCLUSIONS: The age-specific criteria for diastolic LV dysfunction were highly consistent across the study populations with an age-standardized prevalence of 22.4% vs. 25.1%.