Pujol-Gimenez, J. (Jonai)

Filtering

2013 - 20153

Settings

Author search.filters.isAuthorOfPublication.8984aa2f-cd7f-49eb-b0ea-7d7ba77fb390

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    The facilitated glucose transporter GLUT12: What do we know and what would we like to know?
    (Springer, 2013) Lostao, M.P. (María Pilar); Gonzalez-Muniesa, P. (Pedro); Barrenetxe, J. (Jaione); Pujol-Gimenez, J. (Jonai)
    Human GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. Glucose has been described as its main substrate, but it also can transport other sugars. In humans, GLUT12 protein is expressed mainly in insulin sensitive tissues. Functional analysis has showed that GLUT12 transports sugars down its concentration gradient, but it can also work as a proton-coupled symporter. Studies from our laboratory, performed in Xenopus laevis oocytes expressing GLUT12, show that glucose uptake increases in the presence of Na+ and induces inward current. These findings suggest a transport mechanism never described for other GLUTs, which would indicate a distinct functional role for GLUT12. In relation with its physiological and pathophysiological function, GLUT12 has been mainly studied due to its role as a secondary insulin-sensitive glucose transporter and its possible implication in impaired insulin signalling pathologies. Its expression in some tumour tissues has been described and recently, it has been proposed as one of the key proteins in the glucose supply to malignant cells. Overall, even though a lot of information about GLUT12 has been released during the last years, its functional characteristics, physiological role or implication in the development of some diseases is still unclear. Therefore, this review of the literature can help to address further investigations needed to elucidate these issues that, in our view, are of great interest mainly due to the direct GLUT12 relation with cancer and probably with diabetes development.
  • Thumbnail Image
    Could GLUT12 be a potential therapeutic target in cancer treatment? A preliminary report
    (Ivyspring International Publisher, 2015) Lostao, M.P. (María Pilar); Idoate, M.A. (Miguel Ángel); Perez-de-Heredia, F. (Fátima); Airley, R. (Rachel); Pujol-Gimenez, J. (Jonai); Evans, A.R. (Andrew Robert)
    Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment.
  • Thumbnail Image
    Perfil neuropsicológico de la degeneración lobar frontotemporal
    (Gobierno de Navarra, 2015) Lamet, I. (Isabel); Carmona-Abellán, M.M. (María del Mar); Esteve-Belloch, P. (P.); Luquin, M.R. (María Rosario); Riverol, M. (Mario); Pujol-Gimenez, J. (Jonai)
    La degeneración lobar frontotemporal engloba tres síndromes diferentes, que comparten características clínicas y patológicas comunes, dificultando así su diagnóstico en estadios iniciales. Se incluyen en este grupo las tres variantes de la demencia frontotemporal, el síndrome corticobasal y el síndrome de parálisis supranuclear progresiva. Se ha llevado a cabo una revisión del perfil neuropsicológico de cada uno de los síndromes, que permita clarificar las características fundamentales que los definen y ayudar a diferenciarlos de otras demencias. Se ha hecho una revisión de los diferentes trabajos publicados en la literatura al respecto, describiendo las características clínicas, patológicas y los hallazgos de imagen fundamentales de cada entidad para describir de manera exhaustiva los hallazgos en los diferentes dominios neuropsicológicos y su progresión. Aunque existe un solapamiento entre los síndromes que conforman la degeneración lobar frontotemporal, la comparación del perfil neuropsicológico de las mismas entre sí y frente a otras demencias permite establecer características propias de su perfil neuropsicológico para llevar a cabo un diagnóstico diferencial.