Almendral, J. (Jesús)

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    A remote nutritional intervention to change the dietary habits of patients undergoing ablation of atrial fibrillation: randomized controlled trial
    (JMIR Publications, 2020) Martinez-Gonzalez, M.A. (Miguel Ángel); Castellanos, E. (Eduardo); Macias-Ruiz, R. (Rosa); Almendral, J. (Jesús); Barrio-Lopez, M.T. (Maria T.); Ibáñez-Criado, A. (Alicia); Goñi-Mateos, L. (Leticia); Tercedor, L. (Luis); Ruiz-Canela, M. (Miguel); Garcia-Bolao, I. (Ignacio); De-la-O-Pascual, V. (Víctor); Ramos, P. (Pablo); Ibáñez-Criado, J.L. (José Luis)
    Background: The Prevention With Mediterranean Diet (PREDIMED) trial supported the effectiveness of a nutritional intervention conducted by a dietitian to prevent cardiovascular disease. However, the effect of a remote intervention to follow the Mediterranean diet has been less explored. Objective: This study aims to assess the effectiveness of a remotely provided Mediterranean diet–based nutritional intervention in obtaining favorable dietary changes in the context of a secondary prevention trial of atrial fibrillation (AF). Methods: The PREvention of recurrent arrhythmias with Mediterranean diet (PREDIMAR) study is a 2-year multicenter, randomized, controlled, single-blinded trial to assess the effect of the Mediterranean diet enriched with extra virgin olive oil (EVOO) on the prevention of atrial tachyarrhythmia recurrence after catheter ablation. Participants in sinus rhythm after ablation were randomly assigned to an intervention group (Mediterranean diet enriched with EVOO) or a control group (usual clinical care). The remote nutritional intervention included phone contacts (1 per 3 months) and web-based interventions with provision of dietary recommendations, and participants had access to a web page, a mobile app, and printed resources. The information is divided into 6 areas: Recommended foods, Menus, News and Online resources, Practical tips, Mediterranean diet classroom, and Your personal experience. At baseline and at 1-year and 2-year follow-up, the 14-item Mediterranean Diet Adherence Screener (MEDAS) questionnaire and a semiquantitative food frequency questionnaire were collected by a dietitian by phone.
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    Mediterranean diet and epicardial adipose tissue in patients with atrial fibrillation treated with ablation: a substudy of the 'PREDIMAR' trial
    (2023) Martinez-Gonzalez, M.A. (Miguel Ángel); Martínez-Valiente, A. (Almudena); Castellanos, E. (Eduardo); Almendral, J. (Jesús); Barrio-Lopez, M.T. (Maria T.); Goñi-Mateos, L. (Leticia); Díaz-Anton, B. (Belén); Fernández-Friera, L. (Leticia); Ruiz-Canela, M. (Miguel); Romero-García, S. (Silvia); O, V. (Víctor) de la
    Aims To analyse the relationship between Mediterranean diet (MedDiet) adherence and epicardial adipose tissue (EAT) in patients with atrial fibrillation (AF) and the association between EAT or MedDiet adherence at baseline with AF recurrence after ablation.Methods and results We included 199 patients from the PREDIMAR trial (PREvencion con DIeta Mediterranea de Arritmias Recurrentes), in a single centre in this substudy. All of them had a computed tomography with EAT measurement. Lifestyle and clinical characteristics were obtained at baseline. The traditional MedDiet pattern was defined according to the MedDiet Adherence Screener (MEDAS). Any documented AF > 30 s after ablation was considered a recurrence. Multivariable-adjusted linear and logistic regression models were run to assess the cross-sectional association of MedDiet with EAT, and of EAT with the AF type at baseline. Also, Cox regression models were used to prospectively assess the associations of MedDiet adherence and EAT with AF recurrences after ablation. Median EAT was 135 g (interquartile range: 112-177), and the mean MedDiet score was 7.75 +/- 2 points. A higher MEDAS >= 7 that was associated with lower odds of an EAT >= 135 g [multivariable odds ratio (mOR) = 0.45; 95% CI = 0.22-0.91; P = 0.025] was significantly associated with persistent AF after adjusting for traditional risk factors (mOR: 2.22; 95% CI: 1.03-4.79; P = 0.042). No significant associations were observed between EAT >= 135 g and the risk of atrial tachyarrhythmia recurrences after ablation [multivariable-adjusted hazard ratio (mHR) = 1.18; 95% CI: 0.72-1.94; P = 0.512], or between MEDAS >= 7 and AF recurrence (mHR = 0.78; 95% CI: 0.47-1.31; P = 0.344).Conclusion In patients with AF, higher adherence to MedDiet is associated with a significantly lower amount of EAT. Epicardial adipose tissue >= 135 g was significantly associated with persistent AF.