Acín-Pérez, R. (Rebeca)
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- Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts(Nature Research, 2018) González-Aseguinolaza, G. (Gloria); Torralba, D. (Daniel); Villarroya-Beltri, C. (Carolina); Latorre-Pellicer, A. (Ana); Martín-Cófreces, N.B. (Noa B.); Jorge, I. (Inmaculada); Vicente-Manzanares, M. (Miguel); Iborra, S. (Salvador); Baixauli, F. (Francesc); Mittelbrunn, M. (Maria); Enríquez, J.A. (José Antonio); Fernández-Delgado, I. (Irene); Acín-Pérez, R. (Rebeca); Garaude, J. (Johan); Sánchez-Madrid, F. (Francisco); Jaso-Tamame, A.L. (Angel Luis)Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate anti-pathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.