Hontanilla, B. (Bernardo)
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- Innervation of a prefabricated flap: a new experimental model(Hindawi Publishing Corporation, 2014) Geuna, S. (Stefano); Raimondo, S. (Stefania); Romeo, M. (Marco); Qiu, S.S. (Shan Shan); Cuccia, G. (Giuseppe); Hontanilla, B. (Bernardo)Introduction. Flap innervation by neoaxonogenesis is a promising field of investigation. The authors evaluated the possibility of innervating an acellular collagen scaffold as component of a potential prefabricated flap. Materials and Methods. Collagen matrix sheets were implanted around the femoral bundle of a murine model to produce two flaps on proximal and distal nerve stumps based on a flow-through model. After thirty days, nerve regeneration and integration into the collagen matrix were evaluated. The specimens were microscopically analyzed to study Schwann cell colonization and axonal integration with the matrix. Axonal count and density were assessed and statistically evaluated. Results. Qualitative structural and ultrastructural evaluation indicated integration, with axonal fibers merged within the collagen matrix, along with a newly formed vascular network on the proximal flap. Wallerian degeneration occurred inside the distal chamber. Axonal count and density did not show statistically significant differences between the nerve inside the proximal flap and the control side. Conclusions. Innervation of an acellular matrix can be obtained by direct nerve stump implantation. The flow-through system was relatively easy to build and reliable to provide adequate blood supply. The collagen scaffold may be a promising support or further studies of preinnervated microsurgical flaps.
- The Man of the Shroud of Turin: Is He Dead or Alive?(Uniwersytet Mikołaja Kopernika, 2022) Hontanilla, B. (Bernardo)It has been assumed that the person represented on the Shroud of Turin is dead and the image corresponds to a person dead from crucifixion. We have conducted an analysis of the cadaveric data of a body and the presence of face life signs and we could think that the image could corresponds to a living person. Therefore, it might correspond to a man starting a getting up gesture. If we examine the Gospels, a remarkable symmetry is found between the data obtained from the image and the events described in the Gospels, regarding the death and resurrection of Jesus.
- Signs of Life in the Figure of the Shroud of Turin(Uniwersytet Mikołaja Kopernika, 2020) Hontanilla, B. (Bernardo)En este artículo se exponen varios signos de vida que presenta la Síndone de Turín. En base al desarrollo de la rigidez cadavérica, se analiza la postura del cuerpo impreso en la Síndone. Igualmente, la presencia de surcos faciales indica que la per-sona está viva. Por tanto, la Sábana de Turín muestra a la vez signos de muerte como de vida de una persona que dejó su imagen impresa en un momento en el que estaba viva. Si la Síndone es un fraude, se trataría de una obra de arte realizada por un genio con conocimientos médicos, forenses y procesado de imagen de al menos el siglo XX. Si seguimos el relato evangélico observamos que existe una correcta simetría entre los datos presentes en la imagen y lo descrito en los mismos, tanto de la muerte como de la resurrección.
- Breast implant capsule: A murine model comparing capsular contracture susceptibility among six breast implants available in the market(Springer, 2023) Bérniz-Laborda, C.P. (C. P.); Pozo, J.L. (José Luis) del; Carmona-Torre, F. (Francisco de A.); Fernández-Ciriza, L. (Leire); Hontanilla, B. (Bernardo); Gómez-Martínez de Lecea, C. (Cristina)Background Breast implant capsule development and behavior are mainly determined by implant surface combined with other external factors such as intraoperative contamination, radiation or concomitant pharmacologic treatment. Thus, there are several diseases: capsular contracture, breast implant illness or Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL), that have been correlated with the specific type of implant placed. This is the first study to compare all major implant and texture models available in the market on the development and behave of the capsules. Through a histopathological analysis, we compared the behavior of different implant surfaces and how different cellular and histological properties give rise to different susceptibilities to develop capsular contracture among these devices. Methods A total of 48 Wistar female rats were used to implant 6 different types of breast implants. Mentor®, McGhan®, Polytech polyurethane®, Xtralane®, Motiva® and Natrelle Smooth® implants were employed; 20 rats received Motiva®, Xtralane® and Polytech polyurethane®, and 28 rats received Mentor®, McGhan® and Natrelle Smooth® implants. The capsules were removed five weeks after the implants placement. Further histological analysis compared capsule composition, collagen density and cellularity. Results High texturization implants showed the highest levels of collagen and cellularity along the capsule. However, polyurethane implants capsules behaved differently regarding capsule composition, with the thickest capsules but fewer collagen and myofibroblasts than expected, despite being generally considered as a macrotexturized implant. Nanotextured implants and microtextured implants histological findings showed similar characteristics and less susceptibility to develop a capsular contracture compared with smooth implants. Conclusions This study shows the relevance of the breast implant surface on the definitive capsules’ development, since this is one of the most differentiated factors that determine the incidence of capsular contracture and probably other diseases like BIA-ALCL. A correlation of these findings with clinical cases will help to unify implant classification criteria based on their shell and their estimated incidence of capsule-associated pathologies. Up to this point, the establishment of additional groups is recommended as nanotexturized implants seem to behave differently to pure smooth surfaces and polyurethane implants present diverse features from macro- or microtextured implants. No Level Assigned This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
- Belleza y cirugía estética: consideraciones psicológicas y morales(Servicio de Publicaciones de la Universidad de Navarra, 2002) Hontanilla, B. (Bernardo); Auba, C. (Cristina)