Menendez, J.A. (Javier A.)

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    Virgin olive oil and health: summary of the III international conference on virgin olive oil and health consensus report, JAEN (Spain) 2018
    (MDPI AG, 2019) Castañer, O. (Olga); Martinez-Gonzalez, M.A. (Miguel Ángel); Fito, M. (Montserrat); Schwingshackl, L. (Lukas); Toledo, E. (Estefanía); Tsatsakis, A.M. (Aristidis M.); Papadaki, A. (Angeliki); Parrón, T. (Tesifón); Delgado-Rodriguez, M. (Miguel); Sánchez-Quesada, C. (Cristina); Alarcón-de-la-Lastra, C. (Catalina); Pereira, J.E. (Jorge E.); Visioli, F. (Francesco); Gaforio, J.J. (José Juan); Rosillo, M.A. (María A.); Menendez, J.A. (Javier A.); Osada, J. (Jesús) de la; Huertas, J.R (Jesús R.); Hernández, A.F. (Antonio F.)
    The Mediterranean diet is considered as the foremost dietary regimen and its adoption is associated with the prevention of degenerative diseases and an extended longevity. The preeminent features of the Mediterranean diet have been agreed upon and the consumption of olive oil stands out as the most peculiar one. Indeed, the use of olive oil as the nearly exclusive dietary fat is what mostly characterizes the Mediterranean area. Plenty of epidemiological studies have correlated that the consumption of olive oil was associated with better overall health. Indeed, extra virgin olive oil contains (poly)phenolic compounds that are being actively investigated for their purported biological and pharma-nutritional properties. On 18 and 19 May 2018, several experts convened in Jaen (Spain) to discuss the most recent research on the benefits of olive oil and its components. We reported a summary of that meeting (reviewing several topics related to olive oil, not limited to health) and concluded that substantial evidence is accruing to support the widespread opinion that extra virgin olive oil should, indeed, be the fat of choice when it comes to human health and sustainable agronomy.
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    Serum HER-2 concentration is associated with insulin resistance and decreases after weight loss.
    (BioMed Central, 2010) Martin, A. (Alejandro); Frühbeck, G. (Gema); Ricart, W. (Wifredo); Moreno-Navarrete, J. (José); Menendez, J.A. (Javier A.); Fernandez-Real, J.M. (José Manuel)
    HER2/neu is a member of the epidermal growth factor receptor family easily detectable in the serum of cancer patients. We aimed to evaluate circulating HER-2 concentrations in association with insulin resistance in healthy and obese subjects. METHODS: Insulin sensitivity (minimal model) and serum HER-2 concentrations were evaluated in a cross sectional study in men (cohort 1, n = 167) and longitudinally after weight loss in obese subjects (cohort 2, n = 30). RESULTS: Serum HER-2 concentrations were positively associated with BMI and waist circumference (both r = 0.18, p = 0.02), post-load glucose (r = 0.28, p = 0.001) and fasting triglycerides (r = 0.26, p = 0.001); and negatively associated with insulin sensitivity (r = -0.29, p = 0.002, n = 109). Subjects with type 2 diabetes showed significantly increased soluble serum HER-2 concentrations. In different multivariate regression models, fasting triglycerides emerged as the factor that independently contributed to 10-11% of serum HER-2 variance.Serum HER-2 concentrations correlated significantly with fasting triglycerides and insulin sensitivity index in subjects from cohort 2. Weight loss led to a significant decrease of serum HER-2 concentrations. The change in serum HER-2 concentrations were significantly associated with the change in percent body fat and fasting triglycerides in young (below the median age of the cohort) subjects. CONCLUSIONS: Serum HER-2 concentrations might be implicated in the pathophysiology of insulin resistance and associated comorbidities.