Pereira, S. (Sheila)

Filtering

20232

Settings

Author search.filters.isAuthorOfPublication.9d46952d-8a28-4989-bc03-171a6f012375

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Drug-loaded PCL electrospun nanofibers as anti-pancreatic cancer drug delivery systems
    (Springer, 2023-07) Arana-Alonso, S. (Sergio); Riera-Pons, M. (Marc); Padillo-Ruiz, J. (Javier); Mitxelena-Iribarren, O. (Oihane); Pereira, S. (Sheila); Calero-Castro, F.J.(Francisco José); Mujika-Garmendia, M. (Maite); Castillo-Tuñon, J.M.(Juan Manuel)
    Cancer is one of the main causes of death worldwide, being pancreatic cancer the second deadliest cancer in Western countries. Surgery, chemotherapy and radiotherapy form the basis of pancreatic cancer's current treatment. However, these techniques have several disadvantages, such as surgery complications, chemotherapy systemic side effects and cancer recurrence. Drug delivery systems can reduce side effects, increasing the effectivity of the treatment by a controlled release at the targeted tumor cells. In this context, coaxial electrospun fibers can increase the control on the release profile of the drug. The aim of this study was to encapsulate and release different anticancer drugs (5-Fluorouracil and Methotrexate) from a polymeric fiber mat. Different flows and ratios were used to test their effect on fiber morphology, FTIR spectrum, drug encapsulation and release. Good integration of the anticancer drugs was observed and the use of a desiccator for 24 h showed to be a key step to remove solvent remanence. Moreover, the results of this study demonstrated that the polymeric solution could be used to encapsulate and release different drugs to treat cancers. This makes coaxial electrospinning a promising alternative to deliver complex chemotherapies that involve more than one drug, such as FOLFIRINOX, used in pancreatic cancer treatment.
  • Thumbnail Image
    TARTESSUS: A Customized Electrospun Drug Delivery System Loaded with Irinotecan for Local and Sustained Chemotherapy Release in Pancreatic Cancer
    (MDPI, 2023-02) Arana-Alonso, S. (Sergio); Astigarraga, M.(Malen); Padillo-Ruiz, J. (Javier); Mitxelena-Iribarren, O. (Oihane); Pereira, S. (Sheila); Calero-Castro, F.J.(Francisco José); Mujika-Garmendia, M. (Maite); Castillo-Tuñon, J.M.(Juan Manuel); Laga, I. (Iman); Cepeda-Franco, C. (Carmen)
    Post-surgical chemotherapy in pancreatic cancer has notorious side effects due to the high dose required. Multiple devices have been designed to tackle this aspect and achieve a delayed drug release. This study aimed to explore the controlled and sustained local delivery of a reduced drug dose from an irinotecan-loaded electrospun nanofiber membrane (named TARTESSUS) that can be placed on the patients' tissue after tumor resection surgery. The drug delivery system formulation was made of polycaprolactone (PCL)...