Ortigosa, C.R. (C.R.)

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    Leukotriene C4 detection as an early graft function marker in liver transplantation
    (Elsevier, 1992) Pardo, F. (Fernando); Álvarez-Cienfuegos, J. (Javier); Sola, J. (Josu); Hernandez-Lizoain, J.L. (Jose Luis); Ortigosa, C.R. (C.R.); Benito, C. (C.); Balen, E. (Enrique); Pardo-Mindan, F.J. (Francisco Javier); Quiroga, J. (Jorge); Gonzalez, J. (J.)
    Leukotrienes are a group of compounds belonging to the eicosanoid family that are formed from the metabolism of arachidonic acid by means of 5-lipoxigenase. Leukotriene C4 (LTC4) has a pronounced proinflammatory character and is formed by combining leukotriene A4 with glutation. This step is catalyzed mainly by the isoenzyme 4-4 of the hepatic glutation transferases, although other enzymes may participate in its formation. The liver plays a decisive part in the formation of this compound despite the fact that it can be synthesized along other cellular lines. In orthotopic liver transplant (OLT), the evaluation of the early functioning of the graft is, in many cases, complex. The difficulty of evaluation lies in the absence of specific markers to indicate when the transplanted organ will prove viable notwithstanding the damage resulting from preservation, and when these lesions are irreversible. The aim of this study is to determine whether there is a relationship between the ability to synthesize LTC4 immediately after OLT and the early functioning of the graft.
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    Plasma levels of leukotriene B4 during hepatic allograft rejection
    (Elsevier, 1992) Diaz, M.C. (M. C.); Pardo, F. (Fernando); Álvarez-Cienfuegos, J. (Javier); Hernandez-Lizoain, J.L. (Jose Luis); Torramade, J. (J.); Ortigosa, C.R. (C.R.); Pardo-Mindan, F.J. (Francisco Javier); Villa, V. (V.) de; Gonzalez, J. (J.)
    At the present time, rejection is the most frequent cause of graft dysfunction in liver transplantation. Differential diagnosis between this and other possible causes of dysfunction—preservation injury, vascular, biliary, viral—may well be difficult, as the clinical and analytical findings are often similar; moreover, no markers specific to rejection are available, and histological studies are necessary for a definitive diagnosis. For this reason, markers indicating activity within the immune system need to be established so as to provide a more specific means of distinguishing rejection from other causes of graft dysfunction. The immune response to an allograft is complex, and the intricate mechanisms regulating it are still not entirely understood. Nevertheless, several specialists have drawn connections among changes in the lymphocyte subpopulations, rises in the interleukin-2 levels, expression of the interleukin-2 receptor, and alteration in the expression of antigens belonging to class II in the greater complex of histocompatibility, with rejection of the allograft. Leukotriene B4 (LTB4) is a derivative of the metabolism of arachidonic acid via 5- lipoxygenase, whose in vitro behaviour is to encourage rejection by favoring leukocyte aggregation, proliferation of T lymphocytes, interleukin-1 and -2 secretion, and the development of "natural killer" cell subpopulations. This study examines the role of LTB4 in mediating the immune response to the hepatic allograft in order to assess its usefulness in early diagnosis of rejection.