Sobrino-Márquez, J.M. (Jose M.)

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    Incidence and prognosis of colorectal cancer after heart transplantation: data from the Spanish Post-Heart Transplant Tumor Registry
    (2023) Muñiz, J. (Javier); Almenar-Bonet, L. (Luis); Gómez, M. (Manuel); Blasco-Peiro, T. (Teresa); García-Romero, E. (Elena); Garrido-Bravo, I. (Iris); Fuente-Galán, L. (Luis) de la; Sobrino-Márquez, J.M. (Jose M.); Morán, L. (Laura); López-Granados, A. (Amador); Rabago, G. (Gregorio); González-Vílchez, F. (Francisco); Castel-Lavilla, M.A. (Maria Angels); Díaz-Molina, B. (Beatriz); Blázquez-Bermejo, Z. (Zorba); Sagastagoitia-Fornie, M. (Marta); Crespo-Leiro, M.G. (María G.); Mirabet-Pérez, S. (Sonia)
    In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.