Pérez-Fuentes, L. (Laura)

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    Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells
    (Public Library of Science, 2010) Casado, J. (J.A.); Pujol, M.R. (María Roser); Pérez-Fuentes, L. (Laura); Albella, B. (B.); Hanenberg, H. (H.); Surralles, J. (Jordi); Alonso-Ferrero, M. (M.E.); Valeri, A. (Antonio); Bueren, J.A. (Juan A.); Prosper-Cardoso, F. (Felipe); Rio, P. (Paula); Calasanz-Abinzano, M.J. (Maria Jose); Aguirre-Ena, X. (Xabier); Jacome, A. (Ariana)
    Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this genomic instability are still poorly understood. Because the Fanconi anemia (FA) pathway is believed to control several mechanisms of DNA repair, we investigated whether this pathway was disrupted in CML cells. Our data show that CML cells have a defective capacity to generate FANCD2 nuclear foci, either in dividing cells or after DNA damage. Similarly, human cord blood CD34+ cells transduced with BCR/ABL retroviral vectors showed impaired FANCD2 foci formation, whereas FANCD2 monoubiquitination in these cells was unaffected. Soon after the transduction of CD34+ cells with BCR/ABL retroviral vectors a high proportion of cells with supernumerary centrosomes was observed. Similarly, BCR/ABL induced a high proportion of chromosomal abnormalities, while mediated a cell survival advantage after exposure to DNA crosslinking agents. Significantly, both the impaired formation of FANCD2 nuclear foci, and also the predisposition of BCR/ABL cells to develop centrosomal and chromosomal aberrations were reverted by the ectopic expression of BRCA1. Taken together, our data show for the first time a disruption of the FA/BRCA pathway in BCR/ABL cells, suggesting that this defective pathway should play an important role in the genomic instability of CML by the co-occurrence of centrosomal amplification and DNA repair deficiencies.
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    Classical spin dynamics of anisotropic Heisenberg dimmers
    (2013) Laroze, D. (David); Suárez, O.J. (O. J.); Pérez-Fuentes, L. (Laura); Mancini-Maza, H. L. (Hector Luis)
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    Dinámica de un dímero magnético
    (Servicio de Publicaciones de la Universidad de Navarra, 2014) Pérez-Fuentes, L. (Laura); Mancini-Maza, H. L. (Hector Luis)
    Esta memoria de investigación se ha centrado en magnetismo, el cual en general trata sobre el estudio del espín, de sus efectos colectivos, como también en particulas cargadas en movimiento.
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    Caracterización del caos e hipercaos en sistemas magnéticos clásicos
    (2017) Pérez-Fuentes, L. (Laura); Mancini-Maza, H. L. (Hector Luis)
    The aim of the present thesis is to study the dynamics of magnetic systems out of equilibrium. That is, systems where there is a competition between the injection and the dissipation of energy. In particular, the thesis focuses on classic magnetic systems where each magnetic element can be described by a mono-domain, such that the domain does not have spatial inhomogeneities. We study the case of one element (or particle) as well as the case of two interacting particles. The effects of the shape and composition are considered through the magnetic anisotropy energy. We will use homogeneous external fields and time dependent ones. The first two chapters of the thesis are focused on addressing the basic concepts of magnetism as the theoretical framework. Firstly, a brief history of magnetism is given and the types of magnetic materials are presented. Subsequently the equations that govern the dynamics of classical magnetic moments and their fundamental properties are introduced. The scenarios where the system has constants of motion are shown. In addition, a special case of one magnetic particle is studied when a homogeneous external magnetic field is applied. The third chapter deals with the dynamics of a particle with multiple axes of anisotropy in the presence of a time-dependent external field. Regular and chaotic phases are characterized using the Largest Lyapunov exponent within two-dimensional diagrams. Refining the resolution of the diagrams we found regular islands inside of chaotic regions with form of shrimps. In the fourth and fiKh chapters the dynamics of two coupled particles with uniaxial anisotropy is studied. First, the case of exchange interaction with homogeneous external magnetic field is analyzed. The laLer case focuses on dipolar interaction between the particles, such that they are in the presence of a time-dependent field. In both cases, two-dimensional phase diagrams of Lyapunov exponents are using to discriminate the regular phases respect to the chaotic (or hyperchao)c) ones. Furthermore, different types of synchroniza)on between the par)cles are measured. Finally, in the sixth chapter the conclusions and prospects are presented.