Acosta-Alvear, D. (Diego)

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    The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19
    (Wiley, 2020) Michiels, T. (Thomas); Deleuze, J.F. (Jean-Francois); Sluijs, P. (Peter) van der; Danchin, A. (Antoine); Timmis, K.N. (Kenneth N.); Acosta-Alvear, D. (Diego); Delaunay-Moisan, A. (Agnès); Moore, E.R.B. (Edward R. B.); Tillett, D. (Daniel); Aragón-Amonárriz, T. (Tomás); Sitia, R. (Roberto); Braakman, I. (Ineke); Vicenzi, E. (Elisa); Collet, J.F. (Jean-Francois); Nixon-Abell, J. (Jonathon); Siccardi, A.G. (Antonio G.); Armengaud, J. (Jean); Rossello-Mora, R. (Ramon); Anken, E. (Eelco) van; Lucas, S. (Sophie); Blondel, M. (Marc); Courcol, R. (René); Thuret, J.Y. (Jean-Yves); Arias, C. (Carolina); Shi, Z.L. (Zheng-Li); Lavigne, J.P. (Jean-Philippe); Toledano, M.B. (Michel B.)
    The current SARS-CoV-2 pandemic is wreaking havoc throughout the world and has rapidly become a global health emergency. A central question concerning COVID-19 is why some individuals become sick and others not. Many have pointed already at variation in risk factors between individuals. However, the variable outcome of SARS-CoV-2 infections may, at least in part, be due also to differences between the viral subspecies with which individuals are infected. A more pertinent question is how we are to overcome the current pandemic. A vaccine against SARS-CoV-2 would offer significant relief, although vaccine developers have warned that design, testing and production of vaccines may take a year if not longer. Vaccines are based on a handful of different designs (i), but the earliest vaccines were based on the live, attenuated virus. As has been the case for other viruses during earlier pandemics, SARS-CoV-2 will mutate and may naturally attenuate over time (ii). What makes the current pandemic unique is that, thanks to state-of-the-art nucleic acid sequencing technologies, we can follow in detail how SARSCoV-2 evolves while it spreads. We argue that knowledge of naturally emerging attenuated SARS-CoV-2 variants across the globe should be of key interest in our fight against the pandemic.
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    Recent advances in signal integration mechanisms in the unfolded protein response [version 1; peer review: 2 approved]
    (Taylor & Francis, 2019) Karagöz, G.E. (Gulsun Elif); Acosta-Alvear, D. (Diego); Aragón-Amonárriz, T. (Tomás)
    Since its discovery more than 25 years ago, great progress has been made in our understanding of the unfolded protein response (UPR), a homeostatic mechanism that adjusts endoplasmic reticulum (ER) function to satisfy the physiological demands of the cell. However, if ER homeostasis is unattainable, the UPR switches to drive cell death to remove defective cells in an effort to protect the health of the organism. This functional dichotomy places the UPR at the crossroads of the adaptation versus apoptosis decision. Here, we focus on new developments in UPR signaling mechanisms, in the interconnectivity among the signaling pathways that make up the UPR in higher eukaryotes, and in the coordination between the UPR and other fundamental cellular processes.