Leon, P. (Pedro)
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- Esclerosis tuberosa. A propósito de 22 observaciones(Universidad de Navarra, 1997) Narbona, J. (Juan); Jimenez, M. (Miguel); Leon, P. (Pedro); Dwedar, M. (M.)Realizamos una exposición de nuestra casuística, en un periodo comprendido desde 1972 hasta 1991, presentando 22 pacientes con esclerosis tuberosa. Al mismo tiempo realizamos una revisión de la literatura nacional e internacional sobre el tema, destacando sus aspectos epidemiológicos, clínicos, radiológicos, genéticos, diagnósticos, terapéuticos y pronósticos.
- Recombinant Human Erythropoietin for the Treatment of Anemia in Children With Solid Malignant Tumors(Wiley-Blackwell, 1998) Barona, P. (Pascual); Sierrasesumaga, L. (Luis); Jimenez, M. (Miguel); Leon, P. (Pedro)Cancer is often associated with chronic anemia which frequently requires blood transfusions. This study was performed to assess the efficacy and safety of r-HuEPO therapy in children with cancer. PATIENTS AND METHODS: Twenty-five patients under 18 years of age with solid malignant tumors were treated with 150 U/kg/day of r-HuEPO 5 times weekly for 12 weeks. Response was defined as an increase of the baseline hemoglobin level by at least 2 g/dl. r-HuEPO patients were compared to 25 matched historical controls. RESULTS: Response was achieved in 72% of r-HuEPO patients. Hemoglobin level increased from 9.8 +/- 0.6 g/dl at baseline to 12.4 +/- 1.7 g/dl at the end of treatment in the r-HuEPO group and increased from 9.5 +/- 0.7 g/dl to 9.6 +/- 1.4 g/dl in the control group (P < .001, Student's t-test). Only 16% of patients receiving r-HuEPO required blood transfusions vs 96% of control patients (P < .001, Student's t-test), with mean units of blood transfused per patient being 0.35 in the r-HuEPO group and 3.56 in controls (P < .001, Student's t-test). There was a statistically significance improvement in Karnofsky's index in r-HuEPO patients. No adverse reaction related to r-HuEPO therapy was observed. CONCLUSIONS: r-HuEPO is a safe and effective means of increasing hemoglobin level and reducing blood requirements in children with solid malignant tumors receiving chemotherapy.
- Partial splenic embolization in a child with hereditary spherocytosis(Springer Verlag, 1995) Castro, L. (L.); Sierrasesumaga, L. (Luis); Bilbao, J.I. (José I.); Azcona-San-Julian, M.C. (María Cristina); Jimenez, M. (Miguel); Leon, P. (Pedro)