Cabrera-Freitag, P. (Paula)
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- Mobile app/web platform for monitoring food oral immunotherapy in children: longitudinal clinical validation study(JMIR, 2024) López-de-Calle, M. (Marta); Sánchez-Fernández, S. (Sergio); Goikoetxea-Lapresa, M.J. (María José); Lasa, E.M. (Eva María); Cabrera-Freitag, P. (Paula); Terrados, S. (Soledad); Martínez-Molina, S. (Sara); Sola-Martínez, F.J. (Francisco Javier)Background: Milk and egg allergies significantly impact the quality of life, particularly in children. In this regard, food oral immunotherapy (OIT) has emerged as an effective treatment option; however, the occurrence of frequent adverse reactions poses a challenge, necessitating close monitoring during treatment. Objective: This study aims to evaluate the ability of a new mobile/web app called OITcontrol to monitor milk and egg OIT. Methods: Patients undergoing milk or egg OIT were recruited and divided into 2 groups: the active group used the OITcontrol app in conjunction with standard written monitoring methods, whereas the control group relied solely on written diaries. Investigators documented hospital doses, hospital reactions, and administered treatments on the website. Patients recorded their daily allergen home-dose intake, home reactions, and administered treatments using the app. The following variables were compared between both groups: number and severity of hospital and reported home reactions, patient's adhesion to the OITcontrol app or written diary or both in terms of daily home-dose intake and home reactions recording, and treatment and dose adjustment compliance at home in case of reaction. Results: Sixteen patients were assigned to be monitored using the OITcontrol app along with additional written methods (active group), while 14 patients relied solely on a written paper diary (control group). A similar distribution was observed in terms of sex, age, basal characteristics, allergen treated in OIT, premedication, and sensitization profile. Active patients reported a comparable number of hospital and home reactions compared with the control group. In terms of recording system usage, 13/16 (81%) active patients used the OITcontrol app, while 10/14 (71%) control patients relied on the written diary. Among active patients, 6/16 (38%) used both methods, and 1 active patient used only written methods. However, control patients recorded home reactions more frequently than active patients (P=.009). Among active patients, the app was the preferred method for recording reactions (59/86, 69%), compared with the written diary (15/86, 17%) or both methods (12/86, 14%; P<.001). Treatment compliance in home-recorded reactions was similar between both groups (P=.15). However, treatment indications after an adverse reaction were more frequently followed (P=.04) in reactions recorded solely in the app (36/59, 61%) than in the written diary (29/71, 41%) or both systems (4/12, 33%). Moreover, compliance with dose adjustments after a moderate-severe reaction in home-recorded reactions was higher in the active group than in the control group (P<.001). Home reactions recorded only in the app (16/19, 84%) were more likely to follow dose adjustments (P<.001) than those recorded in the written diary (3/20, 15%) or using both methods (2/3, 67%). Conclusions: The OITcontrol app appears to be a valuable tool for monitoring OIT treatment in children with food allergies. It proves to be a suitable method for recording daily home dose intakes and reactions, and it seems to enhance adherence to treatment indications following an adverse reaction as well as compliance with dose adjustments in home reactions. However, additional studies are necessary to comprehensively grasp the benefits and limitations of using the OITcontrol app in the management of OIT.
- A study of the variability of the in vitro component-based microarray ISAC CDR 103 technique(ESMON Publicidad, 2011) Goikoetxea-Lapresa, M.J. (María José); Gamboa, P.M. (P. M.); Martinez-Aranguren, R. (R.); Cabrera-Freitag, P. (Paula); Fernandez, J. (Javier); Sanz, M.L. (María Luisa); Beorlegui, C. (Carmen)
- ¡Hoy comemos huevo! Recetas para sobrevivir al consumo frecuente de huevo cocinado(Sanidad y Ediciones SL, 2019) Cabrera-Freitag, P. (Paula); D'Amelio-Garofalo, C.M. (Carmen Mariana)La alergia al huevo es en España la segunda causa de alergia alimentaria en niños entre los 3 y los 5 años de edad. Sin embargo, aproximadamente un 70% de los niños alérgicos al huevo tolera huevo cocinado y se ha demostrado que su consumo frecuente contribuye a un adecuado aporte nutricional y puede mejorar la calidad de vida del niño y aumentar la probabilidad de tolerar huevo en cualquier presentación en un futuro.
- Late Reaction to Oral Nystatin: The Importance of Patch Testing(ESMON Publicidad, 2009) Goikoetxea-Lapresa, M.J. (María José); Gastaminza, G. (Gabriel); Cabrera-Freitag, P. (Paula); Borbolla, J.M. (J.M.) de la
- A severe case of lipoatrophy due to human insulin and insulin analogs in a patient with diabetes: is an immunological mechanism involved?(Esmon, 2011) Goikoetxea-Lapresa, M.J. (María José); Gastaminza, G. (Gabriel); Cabrera-Freitag, P. (Paula); Laguna, S. (S.); Escalada, J. (Javier); Sanz, M.L. (María Luisa)The precipitin technique has been used in insulin resistance and immunity studies since the 1940s [7]. In the case described, the technique proved, once again, to be a valid method for choosing the most appropriate insulin. However, whether or not an immunological mechanism was involved in the lipoatrophic process remains uncertain, and further studies with adequate immunological assessment are necessary.
- Is the determination of specific IgE against components using ISAC 112 a reproducible technique?(Public Library of Science, 2014) Trellez, O. (Oswaldo); Goikoetxea-Lapresa, M.J. (María José); Lizaso, M.T. (María T.); Martinez-Aranguren, R. (R.); Cabrera-Freitag, P. (Paula); Garcia, B.E. (Blanca Esther); Sanz, M.L. (María Luisa)The allergen microarray immunoassay, ISAC 112, is a repeatable and reproducible in vitro diagnostic tool for determination of sIgE beyond the own laboratory
- The basophil activation test as a promising diagnostic tool in hypersensitivity to chironomid larvae(ESMON Publicidad, 2011) Javaloyes, G. (G.); Martinez, R. (R.); Cabrera-Freitag, P. (Paula); Sanz, M.L. (María Luisa); Ferrer-Cardona, M. (Marta)