Cervantes-Ibáñez, S. (Sebastián)
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- Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort(MDPI, 2015) Martinez-Gonzalez, M.A. (Miguel Ángel); Eguaras, S. (Sonia); Toledo, E. (Estefanía); Hernandez-Hernandez, A. (Aitor); Cervantes-Ibáñez, S. (Sebastián)Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. We prospectively examined the association between obesity and cardiovascular clinical events (myocardial infarction, stroke or cardiovascular death) after 10.9 years follow-up in 19,065 middle-aged men and women (average age 38 year) according to their adherence to the MedDiet (<6 points or ¥6 points in the Trichopoulou’s Mediterranean Diet Score). We observed 152 incident cases of cardiovascular disease (CVD). An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93–2.25) for ¥25 – <30 kg/m2 of BMI and 2.00 (1.04–3.83) for ¥30 kg/m2 of BMI, compared to a BMI < 25 kg/m2. In contrast, these estimates were 0.77 (0.35–1.67) and 1.15 (0.39–3.43) with good adherence to MedDiet. Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029). Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity.
- Complex brain circuits studied via simultaneous and permanent detection of three transported neuroanatomical tracers in the same histological section.(Elsevier, 2000) Arribas, J. (J.); Wouterlood, F.G. (Floris G.); Erro-Aguirre, M.E (María Elena); Gonzalo, N. (Nancy); Lanciego, J.L. (José Luis); Cervantes-Ibáñez, S. (Sebastián); Gimenez-Amaya, J.M. (José Manuel); Urra, X. (X.)Experimental neuroanatomical tracing methods lie at the basis of the study of the nervous system. When the scientific question is relatively straightforward, it may be sufficient to derive satisfactory answers from experiments in which a single neuroanatomical tracing method is applied. In various scientific paradigms however, for instance when the degree of convergence of two different projections on a particular cortical area or subcortical nucleus is the subject of study, the application of single tracing methods can be either insufficient or uneconomical to solve the questions asked. In cases where chains of projections are the subjects of study, the simultaneous application of two tracing methods or even more may be compulsory. The present contribution focuses on combinations of several neuroanatomical tract-tracing strategies, enabling in the end the simultaneous, unambiguous and permanent detection of three transported markers according to a three-color paradigm. A number of combinations of three tracers or of two tracers plus the immunocytochemical detection of a neuroactive substance can be conceived; we describe several of these combinations implemented by us using the present multitracer protocol.
- Validation study of a Spanish version of the modified Telephone Interview for Cognitive Status (STICS-m)(Elsevier BV, 2019) Martinez-Gonzalez, M.A. (Miguel Ángel); Toledo, E. (Estefanía); Cervantes-Ibáñez, S. (Sebastián); Guillen-Grima, F. (Francisco); Razquin, C. (Cristina); Muñoz-García, M.I. (Mariana Isabel); Toledo, J.B. (J.B.)Objective To compare the Spanish version of the modified Telephone Interview of Cognitive Status (STICS-m) with the Mini-Mental State Examination (MMSE) and predict its ability to detect the development of dementia. Method 106 participants in a dietary intervention trial underwent face-to-face evaluation with the MMSE, and phone interview with the STICS-m. The correlation between STICS-m and MMSE was assessed with the intraclass correlation coefficient (ICC) of consistency. Secondly, 932 participants over 55 years old from the “Seguimiento Universidad de Navarra” cohort were evaluated with the STICS-m and data on dementia diagnosis were gathered (median follow-up time of 6.5 years). A logistic regression model evaluated the association between STICS-m score or 2-year changes in STICS-m score and risk of developing dementia, adjusting for ApoE, age and years of university education. Results The ICC between the MMSE and the STICS-m was 0.31 (95% confidence interval [95%CI]: 0.13-0.48). The adjusted odds ratio (OR) for the development of dementia for each additional point in the baseline STICS-m score was 0.85 (95%CI: 0.72-1.02; p = 0.084). When considering the 2-year change in the STICS-m score as exposure, the OR for the development of dementia was 0.79 (95%CI: 0.67-0.93; p = 0.006). Conclusions The weak correlation between the STICS-m and the MMSE reflects moderate-low concurrent validity. Even so, the STICS-m can be regarded as an useful tool in the epidemiological setting since increasing scores appear to be able to predict a lower risk of developing dementia.